Mouse Anti-DSG3 Recombinant Antibody (
4C2) (V2LY-0725-LY689)

Name: Mouse Anti-DSG3 Recombinant Antibody (4C2)
SKU: V2LY-0725-LY689
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-DSG3 Recombinant Antibody (4C2) (V2LY-0725-LY689) in ELISA

The Binding Activity of Human DSG3 with Anti-DSG3 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized human DSG3 at 2 μg/mL can bind Anti-DSG3 recombinant antibody, the EC50 is 10.16-12.87 ng/mL.

Mouse Anti-DSG3 Recombinant Antibody (4C2) (V2LY-0725-LY689) in ELISA

The Binding Activity of Mouse Dsg3 with Anti-DSG3 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse Dsg3 at 5 μg/mL can bind Anti-DSG3 recombinant antibody, the EC50 is 2.624-3.182 μg/mL.

Mouse Anti-DSG3 Recombinant Antibody (4C2) (V2LY-0725-LY689) in ELISA

The Binding Activity of Human DSG3 with Anti-DSG3 recombinant antibodyActivity: Measured by its binding ability in a functional ELISA. Immobilized Human DSG3 at 2 μg/mL can bind Anti-DSG3 recombinant antibody, the EC50 is 4.552-5.720 ng/mL.

Mouse Anti-DSG3 Recombinant Antibody (4C2) (V2LY-0725-LY689) in ELISA

The Binding Activity of Human DSG3 with Anti-DSG3 recombinant antibodyActivity: Measured by its binding ability in a functional ELISA. Immobilized human DSG3 at 2 μg/mL can bind Anti-DSG3 recombinant antibody. The EC50 is 3.915-4.410 ng/mL.

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4C2

Application

ELISA

Immunogen

Recombinant Human DSG3 protein.

Host Species

Mouse

Specificity

Human, Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, Glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Desmoglein 3

Entrez Gene ID

1830

UniProt ID

P32926

Research Area

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Biological Process

Cell-cell adhesion Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro

Cellular Location

Cell membrane; Desmosome

Topology

Extracellular: 50-615
Helical: 616-640
Cytoplasmic: 641-999

Chi, Z., Balani, J., Gopal, P., Hammer, S., Lewis, C. M., & Peng, L. (2022). Characterization of Desmoglein 3 (DSG3) as a Sensitive and Specific Marker for Esophageal Squamous Cell Carcinoma. Gastroenterology Research and Practice, 2022.

Troeltzsch, M., Künzel, V., Haidari, S., Troeltzsch, M., Otto, S., Ehrenfeld, M., ... & Knösel, T. (2022). Desmoglein-3 overexpression in oral squamous cell carcinoma is associated with metastasis formation and early recurrence: An immunohistochemical study. Journal of Cranio-Maxillofacial Surgery, 50(3), 281-288.

Iriki, H., Takahashi, H., Wada, N., Nomura, H., Mukai, M., Kamata, A., ... & Amagai, M. (2021). Peripheral tolerance by Treg via constraining OX40 signal in autoreactive T cells against desmoglein 3, a target antigen in pemphigus. Proceedings of the National Academy of Sciences, 118(49).

Rehman, A., Huang, Y., & Wan, H. (2021). Evolving Mechanisms in the Pathophysiology of Pemphigus Vulgaris: A Review Emphasizing the Role of Desmoglein 3 in Regulating p53 and the Yes-Associated Protein. Life, 11(7), 621.

Fuchs, M., Sigmund, A. M., Waschke, J., & Vielmuth, F. (2020). Desmosomal hyperadhesion is accompanied with enhanced binding strength of desmoglein 3 molecules. Biophysical journal, 119(8), 1489-1500.

Rehman, A., Cai, Y., Hünefeld, C., Jedličková, H., Huang, Y., Teck Teh, M., ... & Wan, H. (2019). The desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53. Cell death & disease, 10(10), 1-14.

Ri, H., Peiyan, Z., Jianqi, W., Yunteng, Z., Gang, L., & Baoqing, S. (2019). Desmoglein 3 gene mediates epidermal growth factor/epidermal growth factor receptor signaling pathway involved in inflammatory response and immune function of anaphylactic rhinitis. Biomedicine & Pharmacotherapy, 118, 109214.

Apu, E. H., Akram, S. U., Rissanen, J., Wan, H., & Salo, T. (2018). Desmoglein 3–Influence on oral carcinoma cell migration and invasion. Experimental Cell Research, 370(2), 353-364.

Moftah, H., Dias, K., Apu, E. H., Liu, L., Uttagomol, J., Bergmeier, L., ... & Wan, H. (2017). Desmoglein 3 regulates membrane trafficking of cadherins, an implication in cell-cell adhesion. Cell adhesion & migration, 11(3), 211-232.

Mao, X., Cho, M. J. T., Ellebrecht, C. T., Mukherjee, E. M., & Payne, A. S. (2017). Stat3 regulates desmoglein 3 transcription in epithelial keratinocytes. JCI insight, 2(9).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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