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Mouse Anti-E2F2 Recombinant Antibody (2302C4a) (CBMAB-E0661-FY)

This product is mouse antibody that recognizes E2F2. The antibody 2302C4a can be used for immunoassay techniques such as: DB, WB.
See all E2F2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2302C4a
Antibody Isotype
IgG2a
Application
DB, WB

Basic Information

Immunogen
E2F2 antibody was raised in mouse using recombinant Human E2F Transcription Factor 2
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.05% Sodium azide
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
E2F transcription factor 2
Introduction
This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.
Entrez Gene ID
1870
UniProt ID
Q14209
Alternative Names
E2F-2
Research Area
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.
Biological Process
Cell cycle Source: UniProtKB-KW
Intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
Lens fiber cell apoptotic process Source: Ensembl
Negative regulation of sprouting angiogenesis Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of cell cycle Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription initiation from RNA polymerase II promoter Source: ProtInc
Cellular Location
Nucleus
PTM
Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase.

Li, P., Xu, H., Yang, L., Zhan, M., Shi, Y., Zhang, C., ... & Wang, Z. (2022). E2F transcription factor 2-activated DLEU2 contributes to prostate tumorigenesis by upregulating serum and glucocorticoid-induced protein kinase 1. Cell death & disease, 13(1), 1-12.

Lv, H., Yu, J., Zhang, H., Qian, X., Wang, Q., Lu, B., & Sun, Y. (2022). MicroRNA-631 deriving from bone marrow mesenchymal stem cell exosomes facilitates the malignant behavior of non-small cell lung cancer via modulating the E2F family of transcription factor 2/phosphatidylinositol 3‐kinase/Akt signaling pathway. Bioengineered, 13(4), 8382-8395.

Xu, L., Wang, L., Shi, Y., Deng, Y., Oates, J. C., Kamen, D. L., ... & Tsao, B. P. (2022). Up‐Regulated Interleukin‐10 Induced by E2F Transcription Factor 2–MicroRNA‐17‐5p Circuitry in Extrafollicular Effector B Cells Contributes to Autoantibody Production in Systemic Lupus Erythematosus. Arthritis & Rheumatology, 74(3), 496-507.

Li, L., Zhang, Y., Wang, L., & Pan, J. (2021). ChIP-sequencing analysis of E2F transcription factor 2 reveals its role in various biological processes of rheumatoid arthritis synovial fibroblasts. BioScience Trends, 15(2), 132-134.

Li, L., Wang, S., Zhang, Y., & Pan, J. (2021). The E2F transcription factor 2: What do we know?. BioScience Trends.

Mamoor, S. (2021). Differential expression of E2F transcription factor 2 in human epithelial ovarian cancer.

Zhang, R., Wang, L., Pan, J. H., & Han, J. (2018). A critical role of E2F transcription factor 2 in proinflammatory cytokines-dependent proliferation and invasiveness of fibroblast-like synoviocytes in rheumatoid Arthritis. Scientific reports, 8(1), 1-10.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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