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Mouse Anti-ERO1A (AA 90-178) Recombinant Antibody (CBFYE-1203) (CBMAB-E1773-FY)

This product is mouse antibody that recognizes ERO1A. The antibody CBFYE-1203 can be used for immunoassay techniques such as: ELISA, IHC-P, WB.
See all ERO1A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-1203
Antibody Isotype
IgG2b, κ
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
ERO1L partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: DISQCGRRDC AVKPCQSDEV PDGIKSASYK YSEEANNLIE ECEQAERLGA VDESLSEETQ KAVLQWTKHD DSSDNFCEAD DIQSPEAEY
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 90-178

Target

Full Name
Endoplasmic Reticulum Oxidoreductase 1 Alpha
Introduction
ERO1A (Endoplasmic Reticulum Oxidoreductase 1 Alpha) is a Protein Coding gene. Diseases associated with ERO1A include Cholera. Among its related pathways are Peptide hormone metabolism and Detoxification of Reactive Oxygen Species. An important paralog of this gene is ERO1B.
Entrez Gene ID
30001
UniProt ID
Q96HE7
Alternative Names
Endoplasmic Reticulum Oxidoreductase 1 Alpha; Endoplasmic Reticulum Oxidoreductase Alpha; Endoplasmic Oxidoreductin-1-Like Protein; Oxidoreductin-1-L-Alpha; ERO1-L-Alpha; ERO1-L; ERO1L; ERO1 (S. Cerevisiae)-Like
Research Area
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1.
Biological Process
Animal organ senescence Source: Ensembl
Brown fat cell differentiation Source: Ensembl
Cell redox homeostasis Source: Ensembl
Cellular protein modification process Source: ProtInc
Cellular response to hypoxia Source: Ensembl
Chaperone cofactor-dependent protein refolding Source: UniProtKB
Endoplasmic reticulum unfolded protein response Source: Ensembl
Extracellular matrix organization Source: Ensembl
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: UniProtKB
Peptidyl-proline hydroxylation to 4-hydroxy-L-proline Source: Ensembl
Protein folding Source: ProtInc
Protein folding in endoplasmic reticulum Source: GO_Central
Protein maturation by protein folding Source: Ensembl
Release of sequestered calcium ion into cytosol Source: UniProtKB
Response to endoplasmic reticulum stress Source: UniProtKB
Response to oxidative stress Source: Ensembl
Response to temperature stimulus Source: ProtInc
Cellular Location
Endoplasmic reticulum membrane. The association with ERP44 is essential for its retention in the endoplasmic reticulum.
PTM
N-glycosylated.
The Cys-94/Cys-99 and Cys-394/Cys-397 disulfide bonds constitute the redox-active center. The Cys-94/Cys-99 disulfide bond may accept electron from P4HB and funnel them to the active site disulfide Cys-394/Cys-397 (By similarity). The regulatory Cys-99/Cys-104 disulfide bond stabilizes the other regulatory bond Cys-94/Cys-131 (PubMed:23027870).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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