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Rabbit Anti-FAS Recombinant Antibody (CBYY-C0206) (CBMAB-C0582-YY)

This product is rabbit antibody that recognizes FAS. The antibody CBYY-C0206 can be used for immunoassay techniques such as: FC
See all FAS antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
CBYY-C0206
Antibody Isotype
IgG
Application
FC

Basic Information

Immunogen
Recombinant Mouse CD95/APO-1/TNFRSF6/FAS protein. This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD95/APO-1/TNFRSF6/FAS
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Affinity purified
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fas Cell Surface Death Receptor
Entrez Gene ID
14102
UniProt ID
Q8C350
Alternative Names
Cadherin 1; Cadherin 1, Type 1, E-Cadherin (Epithelial); Epithelial Cadherin; E-Cadherin; CAM 120/80; Uvomorulin; CDHE; UVO; Calcium-Dependent Adhesion Protein, Epithelial; Cadherin 1, E-Cadherin (Epithelial);
Research Area
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Biological Process
Activation-induced cell death of T cells Source: GO_Central
Apoptotic process Source: MGI
Cellular response to amino acid starvation Source: CAFA
Cellular response to hyperoxia Source: UniProtKB
Cellular response to mechanical stimulus Source: UniProtKB
Extrinsic apoptotic signaling pathway Source: UniProtKB
Extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
Fas signaling pathway Source: CAFA
Immune response Source: InterPro
Motor neuron apoptotic process Source: GO_Central
Necroptotic signaling pathway Source: BHF-UCL
Negative regulation of apoptotic process Source: GO_Central
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of apoptotic signaling pathway Source: CAFA
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: CAFA
Positive regulation of protein phosphorylation Source: CAFA
Protein-containing complex assembly Source: ProtInc
Regulation of apoptotic process Source: UniProtKB
Regulation of stress-activated MAPK cascade Source: CAFA
Signal transduction Source: ProtInc
Cellular Location
Isoform 1: Cell membrane; Membrane raft
Isoform 2&3&4&5&6: Secreted
Involvement in disease
Autoimmune lymphoproliferative syndrome 1A (ALPS1A):
A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia.
Topology
Extracellular: 26-173
Helical: 174-190
Cytoplasmic: 191-335
PTM
(Microbial infection) Glycosylated at Arg-250 by enteropathogenic E.coli protein NleB1: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions.
Palmitoylated (PubMed:25301068). Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane (PubMed:25301068).
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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