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Rat Anti-FCGR3 Recombinant Antibody (2.4G2) (CBMAB-F0625-CQ)

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Datasheet
SDS
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rat
Clone
2.4G2
Application
FC, FuncS, IF, IP
Specificity
Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Fc Fragment Of IgG Receptor IIIa
Entrez Gene ID
14131
UniProt ID
E9PUV2
Alternative Names
Fcgr3; CD16
Research Area
Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.
Biological Process
Cell surface receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Regulation of immune response Source: GO_Central
Cellular Location
Secreted; Cell membrane. Exists also as a soluble receptor.
Involvement in disease
Immunodeficiency 20 (IMD20):
A rare autosomal recessive primary immunodeficiency characterized by functional deficiency of NK cells. Affected individuals typically present with severe herpes viral infections, particularly Epstein Barr virus (EBV), and human papillomavirus (HPV).
Topology
Extracellular: 17-208
Helical: 209-229
Cytoplasmic: 230-254
PTM
Glycosylated. Contains high mannose- and complex-type oligosaccharides. Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms.
The soluble form is produced by a proteolytic cleavage.

DeVault, V. L., Malagic, M., Mei, L., Dienz, O., Lilley, G. W., Benoit, P., ... & Boyson, J. E. (2019). Regulation of invariant NKT cell development and function by a 0.14 Mbp locus on chromosome 1: A possible role for Fcgr3. Genes & Immunity, 20(4), 261-272.

Mei, J., Zhou, W. J., Zhu, X. Y., Lu, H., Wu, K., Yang, H. L., ... & Li, M. Q. (2018). Suppression of autophagy and HCK signaling promotes PTGS2high FCGR3− NK cell differentiation triggered by ectopic endometrial stromal cells. Autophagy, 14(8), 1376-1397.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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