Sign in or Register   Sign in or Register
  |  

Mouse Anti-FCGR3B Recombinant Antibody (CB211) (CBMAB-CS211LY)

The product is antibody recognizes FCGR3B. The antibody CB211 immunoassay techniques such as: IF, FC.
See all FCGR3B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CB211
Antibody Isotype
IgG1
Application
IF, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.2% BSA
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Fc Fragment Of IgG Receptor IIIb
Introduction
The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]
Entrez Gene ID
2215
UniProt ID
O75015
Alternative Names
CD16B; FCG3; FCGR3; IGFR3; Low affinity immunoglobulin gamma Fc region receptor III-B; Fc-gamma RIII-beta; Fc-gamma RIII; Fc-gamma RIIIb; FcRIII; FcRIIIb; FcR-10; IgG Fc receptor III-1; CD antigen CD16b
Research Area
Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
Biological Process
Cell surface receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Regulation of immune response Source: GO_Central
Cellular Location
Cell membrane; Secreted. Secreted after cleavage.
PTM
Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3.
The soluble form is produced by a proteolytic cleavage.

Alyasova, A. V., Amoev, Z. V., Shkola, O. O., Novikov, D. V., Selivanova, S. G., & Novikov, V. V. (2022). Messenger RNA of FCGR3A and FCGR3B Genes as Monitoring Markers of Clear Cell Renal Adenocarcinoma (a Pilot Study). Современные технологии в медицине, 14(3 (eng)), 22-26.

Ines, M., Moalla, M., Aicha, B. T., Selma, B., Leila, R., Rawdha, T., ... & Imen, S. (2022). Impact of FCGR2A R131h, FCGR3A F158V and FCGR3B NA1/NA2 Polymorphisms on Response to Fc-Containing TNF Inhibitor in Rheumatoid Arthritis. FCGR3A F158V and FCGR3B NA1/NA2 Polymorphisms on Response to Fc-Containing TNF Inhibitor in Rheumatoid Arthritis (3/28/2022).

Nassir, N., Tambi, R., Bankapur, A., Al Heialy, S., Karuvantevida, N., Khansaheb, H. H., ... & Uddin, M. (2021). Single-cell transcriptome identifies FCGR3B upregulated subtype of alveolar macrophages in patients with critical COVID-19. Iscience, 24(9), 103030.

Alberici, F., Bonatti, F., Adorni, A., Daminelli, G., Sinico, R. A., Gregorini, G., ... & Vaglio, A. (2020). FCGR3B polymorphism predicts relapse risk in eosinophilic granulomatosis with polyangiitis. Rheumatology, 59(11), 3563-3566.

Dwomoh, D., Adu, B., Dodoo, D., Theisen, M., Iddi, S., & Gerds, T. A. (2020). Evaluating the predictive performance of malaria antibodies and FCGR3B gene polymorphisms on Plasmodium falciparum infection outcome: a prospective cohort study. Malaria Journal, 19(1), 1-12.

Kilani, B., Cornélis, F., Olaso, R., Chaudru, V., & Petit-Teixeira, E. (2019). Investigation of candidate gene copy number identifies FCGR3B as a potential biomarker for rheumatoid arthritis. Clinical and experimental rheumatology, 37(6), 923-928.

Dahmani, C. A., Benzaoui, A., Amroun, H., Zemani‐Fodil, F., Petit‐Teixeira, E., & Boudjema, A. (2019). Association study of copy number variants in CCL3L1, FCGR3A and FCGR3B genes with risk of ankylosing spondylitis in a West Algerian population. International Journal of Immunogenetics, 46(6), 437-443.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-FCGR3B Recombinant Antibody (CB211)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare