Rabbit Anti-FCGR4 Recombinant Antibody (CBFYC-0110) (CBMAB-C0127-FY)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Also acts as a receptor for the Fc region of immunoglobulin epsilon (PubMed:17558411, PubMed:18949059).
Binds with intermediate affinity to both IgG2a and IgG2b (PubMed:16039578, PubMed:17558411, PubMed:19795417).
Can bind to IgG2a and IgG2b monomers (PubMed:18949059).
Does not display binding to IgG1 or IgG3 (PubMed:16039578).
Mediates neutrophil activation by IgG complexes redundantly with Fcgr3 (PubMed:18097064).
Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (PubMed:25824719).
Binds with low affinity to both the a and b allotypes of IgE (PubMed:18949059).
Has also been shown to bind to IgE allotype a only but not to allotype b (PubMed:17558411).
Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes (PubMed:18949059).
Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions (PubMed:17558411, PubMed:18949059).
Cellular response to lipopolysaccharide Source: MGI
Neutrophil activation Source: UniProtKB
Positive regulation of bone resorption Source: UniProtKB
Regulation of immune response Source: GO_Central
Regulation of sensory perception of pain Source: MGI
Wound healing Source: Ensembl
Helical: 204-224
Cytoplasmic: 225-249
Phosphorylated following receptor ligation.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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