Rat Anti-FCGR4 Recombinant Antibody (CBFYC-2701) (CBMAB-C2775-FY)

Name: Rat Anti-FCGR4 Recombinant Antibody (CBFYC-2701)
SKU: CBMAB-C2775-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rat

Clone

CBFYC-2701

Application

Immunogen

Recongnizes an epitope expressed by the murine low affinity Fc receptors, Fc gamma III (CD16) and Fc gamma II (CD32)

Specificity

Mouse

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 1% BSA

Preservative

0.09% Sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fc receptor, IgG, low affinity IV

Introduction

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

246256

UniProt ID

A0A0B4J1G0

Alternative Names

Fcrl3; CD16-2; FcgRIV; Fcgr3a; FcgammaRIV; 4833442P21Rik; low affinity immunoglobulin gamma Fc region receptor IV; Fc fragment of IgG, low affinity IIIa, receptor for (CD16); Fc fragment of IgG, low affinity III, receptor for (CD16); Fc gammaRIV; Fc receptor-like 3; low affinity immunoglobulin gamma Fc region receptor III-A

Research Area

Receptor for the Fc region of immunoglobulin gamma (PubMed:16039578).

Also acts as a receptor for the Fc region of immunoglobulin epsilon (PubMed:17558411, PubMed:18949059).

Binds with intermediate affinity to both IgG2a and IgG2b (PubMed:16039578, PubMed:17558411, PubMed:19795417).

Can bind to IgG2a and IgG2b monomers (PubMed:18949059).

Does not display binding to IgG1 or IgG3 (PubMed:16039578).

Mediates neutrophil activation by IgG complexes redundantly with Fcgr3 (PubMed:18097064).

Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (PubMed:25824719).

Binds with low affinity to both the a and b allotypes of IgE (PubMed:18949059).

Has also been shown to bind to IgE allotype a only but not to allotype b (PubMed:17558411).

Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes (PubMed:18949059).

Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions (PubMed:17558411, PubMed:18949059).

Biological Process

Cell surface receptor signaling pathway Source: GO_Central
Cellular response to lipopolysaccharide Source: MGI
Neutrophil activation Source: UniProtKB
Positive regulation of bone resorption Source: UniProtKB
Regulation of immune response Source: GO_Central
Regulation of sensory perception of pain Source: MGI
Wound healing Source: Ensembl

Cellular Location

Cell membrane. Cell surface expression is dependent on the presence of the Fc receptor gamma chain Fcerg.

Topology

Extracellular: 21-203
Helical: 204-224
Cytoplasmic: 225-249

PTM

N-glycosylated.
Phosphorylated following receptor ligation.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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