Sign in or Register   Sign in or Register
  |  

Mouse Anti-FDXR Recombinant Antibody (CBXF-3763) (CBMAB-F1931-CQ)

This product is a mouse antibody that recognizes FDXR. The antibody CBXF-3763 can be used for immunoassay techniques such as: ELISA, IHC-P, WB.
See all FDXR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-3763
Antibody Isotype
IgG1
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
Purified, recombinant, human ferredoxin reductase protein expressed in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
HEPES, 0.01% BSA, 0.15M NaCl, 50% glycerol
Preservative
0.03% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ferredoxin Reductase
Introduction
This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene.
Entrez Gene ID
2232
UniProt ID
P22570
Alternative Names
Ferredoxin Reductase; Adrenodoxin Reductase; Adrenodoxin-NADP(+) Reductase; Ferredoxin--NADP(+) Reductase; ADXR; AR;
Research Area
Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
Biological Process
Cholesterol metabolic process Source: UniProtKB-UniPathway
Generation of precursor metabolites and energy Source: ProtInc
Steroid biosynthetic process Source: ProtInc
Ubiquinone biosynthetic process Source: GO_Central
Cellular Location
Mitochondrion inner membrane
Involvement in disease
Auditory neuropathy and optic atrophy (ANOA):
An autosomal recessive disease characterized by hearing loss, visual impairment and optic atrophy, with onset in the first or second decades of life. Optic atrophy is caused by degeneration of nerve fibers which arise in the retina and converge to form the optic disk, optic nerve, optic chiasm and optic tracts.

Zhang, Y., Mohibi, S., Vasilatis, D. M., Chen, M., Zhang, J., & Chen, X. (2022). Ferredoxin reductase and p53 are necessary for lipid homeostasis and tumor suppression through the ABCA1–SREBP pathway. Oncogene, 41(12), 1718-1726.

Yang, C., Zhang, Y., Li, J., Song, Z., Yi, Z., Li, F., ... & Wang, C. (2021). Report of a case with ferredoxin reductase (FDXR) gene variants in a Chinese boy exhibiting hearing loss, visual impairment, and motor retardation. International Journal of Developmental Neuroscience, 81(4), 364-369.

Li, M. T., Pi, X. X., Cai, X. L., Liu, S., Huang, Z., Zouboulis, C. C., ... & Shi, G. (2021). Ferredoxin reductase regulates proliferation, differentiation, cell cycle and lipogenesis but not apoptosis in SZ95 sebocytes. Experimental Cell Research, 405(2), 112680.

Sakuma, I., Yokoyama, M., Yamagata, K., Hashimoto, N., Nakayama, A., Shulman, G. I., & Tanaka, T. (2020). MON-635 FDXR Regulates Iron Metabolism and Glucose Metabolism in Liver. Journal of the Endocrine Society, 4(Supplement_1), MON-635.

Zhang, J., Kong, X., Zhang, Y., Sun, W., Wang, J., Chen, M., & Chen, X. (2020). FDXR regulates TP73 tumor suppressor via IRP2 to modulate aging and tumor suppression. The Journal of pathology, 251(3), 284-296.

Cruz-Garcia, L., O’brien, G., Sipos, B., Mayes, S., Tichý, A., Sirák, I., ... & Badie, C. (2020). In vivo validation of alternative FDXR transcripts in human blood in response to ionizing radiation. International journal of molecular sciences, 21(21), 7851.

Slone, J. D., Yang, L., Peng, Y., Queme, L. F., Harris, B., Rizzo, S. J. S., ... & Huang, T. (2020). Integrated analysis of the molecular pathogenesis of FDXR-associated disease. Cell Death & Disease, 11(6), 1-13.

Druck, T., Cheung, D. G., Park, D., Trapasso, F., Pichiorri, F., Gaspari, M., ... & Croce, C. M. (2019). Fhit–Fdxr interaction in the mitochondria: Modulation of reactive oxygen species generation and apoptosis in cancer cells. Cell death & disease, 10(3), 1-10.

Slone, J., Peng, Y., Chamberlin, A., Harris, B., Kaylor, J., McDonald, M. T., ... & Huang, T. (2018). Biallelic mutations in FDXR cause neurodegeneration associated with inflammation. Journal of human genetics, 63(12), 1211-1222.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-FDXR Recombinant Antibody (CBXF-3763)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare