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Rabbit Anti-FGF18 Recombinant Antibody (EG1190) (CBMAB-EN1436-LY)

The product is antibody recognizes FGF18. The antibody EG1190 immunoassay techniques such as: IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:40000.
See all FGF18 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1190
Antibody Isotype
IgG
Application
IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human FGF18.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Fibroblast Growth Factor 18
Introduction
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]
Entrez Gene ID
8817
UniProt ID
O76093
Alternative Names
Fibroblast Growth Factor 18; FGF-18; ZFGF5;
Research Area
Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.
Biological Process
Anatomical structure morphogenesis Source: ProtInc
Angiogenesis Source: Ensembl
Animal organ morphogenesis Source: GO_Central
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Chondrocyte development Source: Ensembl
Endochondral ossification Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: GO_Central
Intramembranous ossification Source: Ensembl
Lung development Source: Ensembl
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of blood vessel endothelial cell migration Source: BHF-UCL
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of chondrocyte differentiation Source: Ensembl
Positive regulation of endothelial cell chemotaxis to fibroblast growth factor Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Positive regulation of gene expression Source: GO_Central
Positive regulation of MAP kinase activity Source: UniProtKB
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of vascular endothelial growth factor receptor signaling pathway Source: Ensembl
Regulation of cell migration Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Secreted

Tong, G., Chen, X., Lee, J., Fan, J., Li, S., Zhu, K., ... & Jin, L. (2022). Fibroblast growth factor 18 attenuates liver fibrosis and HSCs activation via the SMO-LATS1-YAP pathway. Pharmacological Research, 178, 106139.

Estienne, A., Relav, L., Benkoura, M., Monniaux, D., Morin, F., Fabre, S., & Price, C. A. (2022). Endothelial cell‐derived fibroblast growth factor‐18 regulates ovarian function in sheep. Journal of Cellular Physiology.

Li, X. G., Song, X., Wang, J. Y., Sun, C. H., Li, Z. Q., Meng, L. L., & Chi, S. H. (2021). Fibroblast growth factor 18 alleviates hyperoxia-induced lung injury in mice by adjusting oxidative stress and inflammation. European Review for Medical and Pharmacological Sciences, 25(3), 1485-1494.

Li, J., Wang, X., Ruan, G., Zhu, Z., & Ding, C. (2021). Sprifermin: a recombinant human fibroblast growth factor 18 for the treatment of knee osteoarthritis. Expert Opinion on Investigational Drugs, 30(9), 923-930.

da Silva, R. B., Yang, M. Y., Caixeta, E. S., Castilho, A. C., Amorim, R. L., Price, C. A., ... & Buratini, J. (2019). Fibroblast growth factor 18 regulates steroidogenesis in fetal bovine ovarian tissue in vitro. Molecular Reproduction and Development, 86(2), 166-174.

Häckel, S., Zolfaghar, M., Du, J., Hoppe, S., Benneker, L. M., Garstka, N., ... & Li, Z. (2019). Fibrin-hyaluronic acid hydrogel (RegenoGel) with fibroblast growth factor-18 for in vitro 3D culture of human and bovine nucleus pulposus cells. International journal of molecular sciences, 20(20), 5036.

Hagan, A. S., Boylan, M., Smith, C., Perez‐Santamarina, E., Kowalska, K., Hung, I. H., ... & Ornitz, D. M. (2019). Generation and validation of novel conditional flox and inducible Cre alleles targeting fibroblast growth factor 18 (Fgf18). Developmental Dynamics, 248(9), 882-893.

Yao, X., Jing, X., Ye, Y., Guo, J., Sun, K., & Guo, F. (2019). Fibroblast growth factor 18 exerts anti-osteoarthritic effects through PI3K-AKT signaling and mitochondrial fusion and fission. Pharmacological research, 139, 314-324.

Yu, Z., Lou, L., & Zhao, Y. (2018). Fibroblast growth factor 18 promotes the growth, migration and invasion of MDA‑MB‑231 cells. Oncology reports, 40(2), 704-714.

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For research use only. Not intended for any clinical use.

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