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Mouse Anti-FKBP10 Recombinant Antibody (CBXF-1970) (CBMAB-F1105-CQ)

This product is a mouse antibody that recognizes FKBP10. The antibody CBXF-1970 can be used for immunoassay techniques such as: WB, IF, IHC, IP.
See all FKBP10 antibodies

Summary

Host Animal
Mouse
Specificity
Rat, Human, Mouse
Clone
CBXF-1970
Antibody Isotype
IgG1
Application
WB, IF, IHC, IP

Basic Information

Immunogen
Mouse FKBP65 aa. 434-576
Specificity
Rat, Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
FK506 binding protein 10, 65 kDa
Introduction
The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.
Entrez Gene ID
Human60681
Mouse14230
Rat360627
UniProt ID
HumanQ96AY3
MouseQ61576
RatQ5U2V1
Alternative Names
FK506 Binding Protein 10; FK506 Binding Protein 10, 65 KDa; 5 KDa FK506-Binding Protein; Immunophilin FKBP65; PPIase FKBP10; 5 KDa FKBP; EC 5.2.1.8; Rotamase; FKBP-10; FKBP-65;
Function
PPIases accelerate the folding of proteins during protein synthesis.
Biological Process
Aorta morphogenesis Source: Ensembl
Collagen fibril organization Source: Ensembl
Extracellular matrix assembly Source: Ensembl
In utero embryonic development Source: Ensembl
Peptidyl-lysine hydroxylation Source: Ensembl
Peptidyl-proline modification Source: FlyBase
Wound healing Source: Ensembl
Cellular Location
Endoplasmic reticulum lumen
Involvement in disease
Osteogenesis imperfecta 11 (OI11):
A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI11 is an autosomal recessive form.
Bruck syndrome 1 (BRKS1):
A disease characterized by generalized osteopenia, congenital joint contractures, fragile bones with onset of fractures in infancy or early childhood, short stature, severe limb deformity, progressive scoliosis, and pterygia.
PTM
Glycosylated and phosphorylated.

Chen, Z., He, L., Zhao, L., Zhang, G., Wang, Z., Zhu, P., & Liu, B. (2022). circREEP3 drives colorectal cancer progression via activation of FKBP10 transcription and restriction of antitumor immunity. Advanced Science, 9(13), 2105160.

Ma, W., Li, X., Yang, L., Pan, J., Chen, Y., Lu, Y., ... & Gan, W. (2022). High VSX1 expression promotes the aggressiveness of clear cell renal cell carcinoma by transcriptionally regulating FKBP10. Journal of Translational Medicine, 20(1), 1-15.

Lim, J., Lietman, C., Grol, M. W., Castellon, A., Dawson, B., Adeyeye, M., ... & Lee, B. H. (2021). Localized chondro-ossification underlies joint dysfunction and motor deficits in the Fkbp10 mouse model of osteogenesis imperfecta. Proceedings of the National Academy of Sciences, 118(25), e2100690118.

Cai, H. Q., Zhang, M. J., Cheng, Z. J., Yu, J., Yuan, Q., Zhang, J., ... & Wan, J. H. (2021). FKBP10 promotes proliferation of glioma cells via activating AKT-CREB-PCNA axis. Journal of Biomedical Science, 28(1), 1-15.

Yüksel Ülker, A., Uludağ Alkaya, D., Elkanova, L., Şeker, A., Akpınar, E., Akarsu, N. A., ... & Tüysüz, B. (2021). Long-term follow-up outcomes of 19 patients with Osteogenesis Imperfecta type XI and Bruck syndrome type I caused by FKBP10 variants. Calcified Tissue International, 109(6), 633-644.

Costantini, A., Valta, H., Suomi, A. M., Mäkitie, O., & Taylan, F. (2021). Oligogenic inheritance of monoallelic TRIP11, FKBP10, NEK1, TBX5, and NBAS variants leading to a phenotype similar to odontochondrodysplasia. Frontiers in Genetics, 12, 680838.

Ramadori, G., Ioris, R. M., Villanyi, Z., Firnkes, R., Panasenko, O. O., Allen, G., ... & Coppari, R. (2020). FKBP10 regulates protein translation to sustain lung cancer growth. Cell reports, 30(11), 3851-3863.

Wang, R. G., Zhang, D., Zhao, C. H., Wang, Q. L., Qu, H., & He, Q. S. (2020). FKBP10 functioned as a cancer‐promoting factor mediates cell proliferation, invasion, and migration via regulating PI3K signaling pathway in stomach adenocarcinoma. The Kaohsiung Journal of Medical Sciences, 36(5), 311-317.

Liang, L., Zhao, K., Zhu, J. H., Chen, G., Qin, X. G., & Chen, J. Q. (2019). Comprehensive evaluation of FKBP10 expression and its prognostic potential in gastric cancer. Oncology Reports, 42(2), 615-628.

Knüppel, L., Heinzelmann, K., Lindner, M., Hatz, R., Behr, J., Eickelberg, O., & Staab-Weijnitz, C. A. (2018). FK506-binding protein 10 (FKBP10) regulates lung fibroblast migration via collagen VI synthesis. Respiratory Research, 19, 1-14.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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