Mouse Anti-FKBP11 Recombinant Antibody (CBXF-1751) (CBMAB-F3286-CQ)

Name: Mouse Anti-FKBP11 Recombinant Antibody (CBXF-1751)
SKU: CBMAB-F3286-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-1751

Application

WB, IP, IF, ELISA

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

FK506 Binding Protein 11

Introduction

FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rapamycin (Rulten et al., 2006 [PubMed 16596453]).

Entrez Gene ID

Human	51303
Mouse	66120
Rat	300211

UniProt ID

Human	Q9NYL4
Mouse	Q9D1M7
Rat	G3V7V5

Alternative Names

FK506 Binding Protein 11; FK506 Binding Protein 11, 19 KDa; 19 KDa FK506-Binding Protein; PPIase FKBP11; 19 KDa FKBP; Rotamase; FKBP-11;

Function

PPIases accelerate the folding of proteins during protein synthesis.

Biological Process

Chaperone-mediated protein folding Source: InterPro

Cellular Location

Membrane

Topology

Helical: 156-176

Herrema, H., Guan, D., Choi, J. W., Feng, X., Hernandez, M. A. S., Faruk, F., ... & Ozcan, U. (2022). FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity. Cell Metabolism, 34(7), 1004-1022.

Qiu, L., Liu, H., Wang, S., Dai, X. H., Shang, J. W., Lian, X. L., ... & Zhang, J. (2021). FKBP11 promotes cell proliferation and tumorigenesis via p53-related pathways in oral squamous cell carcinoma. Biochemical and Biophysical Research Communications, 559, 183-190.

Wang, X., Cui, X., Zhu, C., Li, M., Zhao, J., Shen, Z., ... & Zhou, G. (2018). FKBP11 protects intestinal epithelial cells against inflammation‑induced apoptosis via the JNK‑caspase pathway in Crohn's disease. Molecular Medicine Reports, 18(5), 4428-4438.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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