Rabbit Anti-FOLR1 Recombinant Antibody (EG1219) (CBMAB-EN1474-LY)

Name: Rabbit Anti-FOLR1 Recombinant Antibody (EG1219)
SKU: CBMAB-EN1474-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG1219

Application

WB: 1:500~1:1000 ELISA: 1:1000

Immunogen

The antibody was produced against synthesized peptide derived from internal of human FOLR1.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

folate receptor alpha

Introduction

The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.

Entrez Gene ID

Human	2348
Mouse	14275
Rat	171049

UniProt ID

Human	P15328
Mouse	P35846
Rat	G3V8M6

Alternative Names

FBP; FOLR; NCFTD; FRalpha

Function

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.

Biological Process

Anterior neural tube closure Source: BHF-UCL
Axon regeneration Source: BHF-UCL
Cardiac neural crest cell migration involved in outflow tract morphogenesis Source: BHF-UCL
Cell adhesion Source: GO_Central
Cellular response to folic acid Source: BHF-UCL
Folate import across plasma membrane Source: InterPro
Folic acid metabolic process Source: Ensembl
Folic acid transport Source: UniProtKB
Fusion of sperm to egg plasma membrane involved in single fertilization Source: GO_Central
Heart looping Source: BHF-UCL
Neural crest cell migration involved in heart formation Source: BHF-UCL
Pharyngeal arch artery morphogenesis Source: BHF-UCL
Receptor-mediated endocytosis Source: ProtInc
Regulation of canonical Wnt signaling pathway Source: BHF-UCL
Regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Sperm-egg recognition Source: GO_Central

Cellular Location

Cell membrane; Apical cell membrane; Endosome; Secreted; Cytoplasmic vesicle; Clathrin-coated vesicle. Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane.

Involvement in disease

Neurodegeneration due to cerebral folate transport deficiency (NCFTD):
An autosomal recessive neurodegenerative disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy and leukodystrophy.

PTM

The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.

Nawaz, F. Z., & Kipreos, E. T. (2022). Emerging roles for folate receptor FOLR1 in signaling and cancer. Trends in Endocrinology & Metabolism, 33(3), 159-174.

Song, X., Wei, J., Shu, J., Liu, Y., Sun, M., Zhu, P., & Qin, J. (2022). Association of polymorphisms of FOLR1 gene and FOLR2 gene and maternal folic acid supplementation with risk of ventricular septal defect: a case-control study. European Journal of Clinical Nutrition, 76(9), 1273-1280.

Jia, L., Li, J., Li, P., Liu, D., Li, J., Shen, J., ... & Sun, S. (2021). Site-specific glycoproteomic analysis revealing increased core-fucosylation on FOLR1 enhances folate uptake capacity of HCC cells to promote EMT. Theranostics, 11(14), 6905.

Karampelias, C., Rezanejad, H., Rosko, M., Duan, L., Lu, J., Pazzagli, L., ... & Andersson, O. (2021). Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation. Nature Communications, 12(1), 3362.

Liang, Z., Dong, J., Yang, N., Li, S. D., Yang, Z. Y., Huang, R., ... & Liang, Z. Q. (2021). Tandem CAR-T cells targeting FOLR1 and MSLN enhance the antitumor effects in ovarian cancer. International Journal of Biological Sciences, 17(15), 4365.

Liu, Y., Lian, T., & Yao, Y. (2020). A systematic review and meta-analysis of higher expression of folate receptor alpha (FOLR1) predicts poor cancer prognosis. Biomarkers, 25(5), 367-374.

Shivange, G., Urbanek, K., Przanowski, P., Perry, J. S., Jones, J., Haggart, R., ... & Tushir-Singh, J. (2018). A single-agent dual-specificity targeting of FOLR1 and DR5 as an effective strategy for ovarian cancer. Cancer cell, 34(2), 331-345.

Kim, M., Pyo, S., Kang, C. H., Lee, C. O., Lee, H. K., Choi, S. U., & Park, C. H. (2018). Folate receptor 1 (FOLR1) targeted chimeric antigen receptor (CAR) T cells for the treatment of gastric cancer. PloS one, 13(6), e0198347.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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