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Mouse Anti-GBP1 (AA 1-593) Recombinant Antibody (CBFYH-0268) (CBMAB-H1142-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0268
Antibody Isotype
IgG2a
Application
IHC-P

Basic Information

Immunogen
Recombinant protein corresponding to aa 1-593 of human GBP1
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-593

Target

Full Name
Guanylate Binding Protein 1
Introduction
Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.
Entrez Gene ID
2633
UniProt ID
P32455
Alternative Names
Guanylate Binding Protein 1; Guanylate Binding Protein 1, Interferon-Inducible, 67kDa; Interferon-Induced Guanylate-Binding Protein 1; Guanine Nucleotide-Binding Protein 1; GTP-Binding Protein 1; HuGBP-1
Function
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.
Biological Process
Cellular response to interferon-gamma Source: UniProtKB
Cellular response to interleukin-1 Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Defense response to virus Source: UniProtKB-KW
Negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
Negative regulation of interleukin-2 production Source: UniProtKB
Negative regulation of protein localization to plasma membrane Source: UniProtKB
Negative regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
Negative regulation of T cell receptor signaling pathway Source: UniProtKB
Protein localization to vacuole Source: UniProtKB
Regulation of calcium-mediated signaling Source: UniProtKB
Regulation of protein localization to plasma membrane Source: UniProtKB
Cellular Location
Cell membrane; Secreted; Cytoplasm; Golgi apparatus membrane. Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of IFNG induction. Golgi membrane localization requires isoprenylation and the presence of another IFNG-induced factor.
PTM
Isoprenylation is required for proper subcellular location.
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For research use only. Not intended for any clinical use.

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