GBP1

Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]
Full Name
Guanylate Binding Protein 1
Function
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.
Biological Process
Cellular response to interferon-gamma Source: UniProtKB
Cellular response to interleukin-1 Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Defense response to virus Source: UniProtKB-KW
Negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
Negative regulation of interleukin-2 production Source: UniProtKB
Negative regulation of protein localization to plasma membrane Source: UniProtKB
Negative regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
Negative regulation of T cell receptor signaling pathway Source: UniProtKB
Protein localization to vacuole Source: UniProtKB
Regulation of calcium-mediated signaling Source: UniProtKB
Regulation of protein localization to plasma membrane Source: UniProtKB
Cellular Location
Cell membrane; Secreted; Cytoplasm; Golgi apparatus membrane. Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of IFNG induction. Golgi membrane localization requires isoprenylation and the presence of another IFNG-induced factor.
PTM
Isoprenylation is required for proper subcellular location.
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Anti-GBP1 antibodies

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Rabbit Anti-GBP1 Recombinant Antibody (EG1295) (CBMAB-EN1566-LY)

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Target: GBP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1295
Application*: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:40000
Datasheet SDS

GBP1 Matched Antibody Pair (468) (APMAB-468LY)

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Target: GBP1
Specificity: Human
Datasheet SDS

GBP1 Matched Antibody Pair (467) (APMAB-467LY)

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Target: GBP1
Specificity: Human
Datasheet SDS

Mouse Anti-GBP1 Recombinant Antibody (CBLG1-726) (CBMAB-G2417-LY)

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Target: GBP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-726
Application*: E, WB
Datasheet SDS

Mouse Anti-GBP1 Recombinant Antibody (CBLG1-725) (CBMAB-G2416-LY)

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Target: GBP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-725
Application*: E, P, WB
Datasheet SDS

Mouse Anti-GBP1 Recombinant Antibody (CBLG1-724) (CBMAB-G2415-LY)

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Target: GBP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-724
Application*: E, P
Datasheet SDS

Mouse Anti-GBP1 Recombinant Antibody (CBLG1-2656) (CBMAB-G2414-LY)

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Target: GBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2656
Application*: WB
Datasheet SDS

Mouse Anti-GBP1 Recombinant Antibody (4D10) (CBMAB-G2412-LY)

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Target: GBP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4D10
Application*: E, P, WB
Datasheet SDS

Rat Anti-GBP1 Recombinant Antibody (1B1) (CBMAB-G2410-LY)

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Target: GBP1
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B1
Application*: IC, IH, WB
Datasheet SDS

Mouse Anti-GBP1 Recombinant Antibody (CBLG1-049) (CBMAB-G0249-LY)

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Target: GBP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-049
Application*: E, IH
Datasheet SDS

Mouse Anti-GBP1 (AA 1-593) Recombinant Antibody (CBFYH-0268) (CBMAB-H1142-FY)

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Target: GBP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-0268
Application*: P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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