GBP1

Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]

Guanylate Binding Protein 1

Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.

Cellular response to interferon-gamma Source: UniProtKB
Cellular response to interleukin-1 Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Defense response to virus Source: UniProtKB-KW
Negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
Negative regulation of interleukin-2 production Source: UniProtKB
Negative regulation of protein localization to plasma membrane Source: UniProtKB
Negative regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
Negative regulation of T cell receptor signaling pathway Source: UniProtKB
Protein localization to vacuole Source: UniProtKB
Regulation of calcium-mediated signaling Source: UniProtKB
Regulation of protein localization to plasma membrane Source: UniProtKB

Cell membrane; Secreted; Cytoplasm; Golgi apparatus membrane. Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of IFNG induction. Golgi membrane localization requires isoprenylation and the presence of another IFNG-induced factor.

Isoprenylation is required for proper subcellular location.