Rat Anti-GDF3 Recombinant Antibody (G0313) (V2LY-1225-LY999)

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Basic Information

Host Animal
Rat
Clone
G0313
Application
WB
Immunogen
E. coli-derived recombinant mouse GDF-3 (Ala253-Gly366).
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
ApplicationNote
WB1 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, trehalose
Preservative
None
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Growth Differentiation Factor 3
Entrez Gene ID
UniProt ID
Function
Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto (By similarity).

Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto (PubMed:21805089).
Biological Process
BMP signaling pathway Source: GO_Central
Eye development Source: UniProtKB
Negative regulation of BMP signaling pathway Source: UniProtKB
Negative regulation of epidermal cell differentiation Source: UniProtKB
Positive regulation of fat cell differentiation Source: BHF-UCL
Positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
Regulation of cell fate commitment Source: UniProtKB
Skeletal system development Source: UniProtKB
SMAD protein signal transduction Source: GO_Central
Cellular Location
Cytoplasm; Secreted. Mainly accumulated in the cytoplasm.
Involvement in disease
Klippel-Feil syndrome 3, autosomal dominant (KFS3):
A skeletal disorder characterized by congenital fusion of cervical vertebrae. It is due to a failure in the normal segmentation of vertebrae during the early weeks of fetal development. The clinical triad consists of short neck, low posterior hairline, and limited neck movement.
Microphthalmia, isolated, with coloboma, 6 (MCOPCB6):
A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure).
Microphthalmia, isolated, 7 (MCOP7):
A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present.
PTM
Synthesized as large precursor molecule that undergo proteolytic cleavage, releasing the pro-domain from the active, receptor binding, C-terminal region of the molecule.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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