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Rabbit Anti-GDNF Recombinant Antibody (BA0214) (CBMAB-0346CQ)

This product is a rabbit antibody that recognizes GDNF. The antibody BA0214 can be used for immunoassay techniques such as: FC, WB.
See all GDNF antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0214
Antibody Isotype
IgG
Application
FC, WB

Basic Information

Immunogen
Human GDNF aa 50-150 (Cysteine residue)
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Glial Cell Derived Neurotrophic Factor
Introduction
This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease.
Entrez Gene ID
Human2668
Mouse14573
Rat25453
UniProt ID
HumanP39905
MouseP48540
RatQ07731
Alternative Names
Glial Cell Derived Neurotrophic Factor; Astrocyte-Derived Trophic Factor; ATF; Glial Cell Line Derived Neurotrophic Factor; Glial Derived Neurotrophic Factor; HFB1-GDNF; HSCR3; HGDNF; ATF1; ATF2
Function
Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
Biological Process
Adult locomotory behavior Source: BHF-UCL
Branching involved in ureteric bud morphogenesis Source: UniProtKB
Commissural neuron axon guidance Source: ARUK-UCL
Dorsal spinal cord development Source: ARUK-UCL
Embryonic organ development Source: ARUK-UCL
Enteric nervous system development Source: UniProtKB
Mesenchymal to epithelial transition involved in metanephros morphogenesis Source: Ensembl
Metanephros development Source: UniProtKB
mRNA stabilization Source: BHF-UCL
Negative regulation of apoptotic process Source: ProtInc
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: UniProtKB
Negative regulation of neuron apoptotic process Source: UniProtKB
Nervous system development Source: ARUK-UCL
Neural crest cell migration Source: MGI
Neuron projection development Source: MGI
Organ induction Source: Ensembl
Peripheral nervous system development Source: GO_Central
Peristalsis Source: UniProtKB
Positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
Positive regulation of cell differentiation Source: MGI
Positive regulation of cell population proliferation Source: MGI
Positive regulation of dopamine secretion Source: BHF-UCL
Positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: Ensembl
Positive regulation of monooxygenase activity Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of ureteric bud formation Source: UniProtKB
Postganglionic parasympathetic fiber development Source: UniProtKB
Postsynaptic membrane organization Source: Ensembl
Regulation of dopamine uptake involved in synaptic transmission Source: UniProtKB
Regulation of gene expression Source: MGI
Regulation of morphogenesis of a branching structure Source: UniProtKB
Regulation of semaphorin-plexin signaling pathway Source: ARUK-UCL
Regulation of stem cell differentiation Source: ParkinsonsUK-UCL
Signal transduction Source: ProtInc
Sympathetic nervous system development Source: UniProtKB
Ureteric bud formation Source: Ensembl
Cellular Location
Secreted
Involvement in disease
Hirschsprung disease 3 (HSCR3):
A disorder of neural crest development characterized by absence of enteric ganglia along a variable length of the intestine. It is the most common cause of congenital intestinal obstruction. Early symptoms range from complete acute neonatal obstruction, characterized by vomiting, abdominal distention and failure to pass stool, to chronic constipation in the older child.
Congenital central hypoventilation syndrome (CCHS):
Rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
Pheochromocytoma (PCC):
A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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