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Mouse Anti-GFAP Monoclonal Antibody (2A5) (CBMAB-1331-YC)

Provided herein is a mouse monoclonal antibody against Pig GFAP. The antibody, clone 2A5, can be used for immunoassay techniques, such as ICC, IF, IHC-Fr, IHC-P, ELISA and WB.
See all GFAP antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
Pig, Mouse, Rat, Cattle, Human
Clone
2A5
Antibody Isotype
IgG1, κ
Application
ICC, IF, IHC-Fr, IHC-P, ELISA, WB

Basic Information

Immunogen
Full length native protein (purified) corresponding to Pig GFAP
Specificity
Pig, Mouse, Rat, Cattle, Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Glial Fibrillary Acidic Protein
Introduction
GFAP is one of the major intermediate filament proteins of mature astrocytes, which is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in GFAP cause Alexander disease, a rare disorder of astrocytes in the central nervous system.
Entrez Gene ID
Human2670
Mouse14580
Rat24387
Pig396562
Cattle281189
UniProt ID
HumanP14136
MouseP03995
RatP47819
PigF1RR02
CattleQ28115
Alternative Names
ALXDRD
Function
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
Biological Process
Astrocyte development Source: Ensembl
Bergmann glial cell differentiation Source: Ensembl
D-aspartate import across plasma membrane Source: Ensembl
Extracellular matrix organization Source: Ensembl
Gene expression Source: Ensembl
Intermediate filament organization Source: UniProtKB
Intracellular protein transport Source: Ensembl
Long-term synaptic potentiation Source: Ensembl
Negative regulation of neuron projection development Source: Ensembl
Neuron projection regeneration Source: Ensembl
Positive regulation of Schwann cell proliferation Source: Ensembl
Regulation of chaperone-mediated autophagy Source: ParkinsonsUK-UCL
Regulation of neurotransmitter uptake Source: Ensembl
Regulation of protein-containing complex assembly Source: ParkinsonsUK-UCL
Response to wounding Source: Ensembl
Cellular Location
Cytoplasm. Associated with intermediate filaments.
Involvement in disease
Alexander disease (ALXDRD):
A rare disorder of the central nervous system. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death within the first decade. Infants with Alexander disease develop a leukodystrophy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course. Histologically, Alexander disease is characterized by Rosenthal fibers, homogeneous eosinophilic inclusions in astrocytes.
PTM
Phosphorylated by PKN1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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