Mouse Anti-GFAP Recombinant Antibody (CBFYH-0330) (CBMAB-H1200-FY)

Name: Mouse Anti-GFAP Recombinant Antibody (CBFYH-0330)
SKU: CBMAB-H1200-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBFYH-0330

Application

IF, IHC, WB

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, PH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% Sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Glial Fibrillary Acidic Protein

Introduction

This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Entrez Gene ID

2670

UniProt ID

P14136

Alternative Names

Glial Fibrillary Acidic Protein; Intermediate Filament Protein; ALXDRD

Function

GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.

Biological Process

Astrocyte development Source: Ensembl
Bergmann glial cell differentiation Source: Ensembl
D-aspartate import across plasma membrane Source: Ensembl
Extracellular matrix organization Source: Ensembl
Gene expression Source: Ensembl
Intermediate filament organization Source: UniProtKB
Intracellular protein transport Source: Ensembl
Long-term synaptic potentiation Source: Ensembl
Negative regulation of neuron projection development Source: Ensembl
Neuron projection regeneration Source: Ensembl
Positive regulation of Schwann cell proliferation Source: Ensembl
Regulation of chaperone-mediated autophagy Source: ParkinsonsUK-UCL
Regulation of neurotransmitter uptake Source: Ensembl
Regulation of protein-containing complex assembly Source: ParkinsonsUK-UCL
Response to wounding Source: Ensembl

Cellular Location

Cytoplasm. Associated with intermediate filaments.

Involvement in disease

Alexander disease (ALXDRD):
A rare disorder of the central nervous system. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death within the first decade. Infants with Alexander disease develop a leukodystrophy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course. Histologically, Alexander disease is characterized by Rosenthal fibers, homogeneous eosinophilic inclusions in astrocytes.

PTM

Phosphorylated by PKN1.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

GFAP Matched Antibody Pair (479) (CAT#: APMAB-479LY)

GFAP Matched Antibody Pair (480) (CAT#: APMAB-480LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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