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Mouse Anti-GNA12 Recombinant Antibody (5E9H9) (CBMAB-G4051-LY)

This product is antibody recognizes GNA12. The antibody 5E9H9 immunoassay techniques such as: WB.
See all GNA12 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
5E9H9
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
guanine nucleotide binding protein, alpha 12
Entrez Gene ID
14673
UniProt ID
P27600
Alternative Names
AI414047; AI504261; Galpha12
Function
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452).

Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387).

GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity).

GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996).

Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452).

Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920).

Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433).

May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).
Biological Process
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
Blood coagulation Source: ProtInc
G protein-coupled receptor signaling pathway Source: ProtInc
Negative regulation of vascular associated smooth muscle cell migration Source: Ensembl
Negative regulation of vascular associated smooth muscle cell proliferation Source: Ensembl
Regulation of fibroblast migration Source: UniProtKB
Regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Regulation of TOR signaling Source: UniProtKB
Response to drug Source: Ensembl
Rho protein signal transduction Source: GO_Central
Cellular Location
Cell membrane; Lateral cell membrane; Cytoplasm. CDH1 enhances cell membrane localization.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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