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Mouse Anti-GNAI2 Recombinant Antibody (CBLG1-1406) (CBMAB-G4103-LY)

This product is antibody recognizes GNAI2. The antibody CBLG1-1406 immunoassay techniques such as: WB.
See all GNAI2 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Guinea pig, Cattle, Rat, Pig, Human
Clone
CBLG1-1406
Antibody Isotype
IgG2b
Application
WB

Basic Information

Specificity
Mouse, Guinea pig, Cattle, Rat, Pig, Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
Introduction
The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Entrez Gene ID
Human2771
Mouse14678
Rat81664
Guinea pig100135529
Cattle281791
Pig397523
UniProt ID
HumanP04899
MouseP08752
RatP04897
Guinea pigP38402
CattleA7MBH9
PigQ06AS6
Function
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.

Isoform sGi2:
Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: Ensembl
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: GO_Central
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB
Cell population proliferation Source: Ensembl
Gamma-aminobutyric acid signaling pathway Source: GO_Central
G protein-coupled acetylcholine receptor signaling pathway Source: Ensembl
G protein-coupled adenosine receptor signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: ProtInc
Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process Source: Ensembl
Negative regulation of adenylate cyclase activity Source: ProtInc
Negative regulation of apoptotic signaling pathway Source: Ensembl
Negative regulation of calcium ion-dependent exocytosis Source: Ensembl
Negative regulation of protein tyrosine phosphatase activity Source: Ensembl
Negative regulation of synaptic transmission Source: Ensembl
Positive regulation of cell migration Source: Ensembl
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Positive regulation of insulin receptor signaling pathway Source: Ensembl
Positive regulation of NAD(P)H oxidase activity Source: Ensembl
Positive regulation of neural precursor cell proliferation Source: Ensembl
Positive regulation of renal sodium excretion Source: Ensembl
Positive regulation of superoxide anion generation Source: Ensembl
Positive regulation of urine volume Source: Ensembl
Positive regulation of vascular associated smooth muscle cell proliferation Source: Ensembl
Regulation of calcium ion transport Source: Ensembl
Response to nutrient Source: ProtInc
Signal transduction Source: ProtInc
Cellular Location
Centrosome; Cell membrane; Cytoplasm; Membrane. Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody.
PTM
(Microbial infection) Deamidated at Gln-205 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA.

Yu, H., Liu, S., Wu, Z., & Gao, F. (2022). GNAI2 Is a Risk Factor for Gastric Cancer: Study of Tumor Microenvironment (TME) and Establishment of Immune Risk Score (IRS). Oxidative Medicine and Cellular Longevity, 2022.

Ha, J. H., Jayaraman, M., Yan, M., Dhanasekaran, P., Isidoro, C., Song, Y. S., & Dhanasekaran, D. N. (2021). GNAi2/gip2-regulated transcriptome and its therapeutic significance in ovarian cancer. Biomolecules, 11(8), 1211.

Chao, M. L., Luo, S., Zhang, C., Zhou, X., Zhou, M., Wang, J., ... & Ji, Y. (2021). S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis. Nature Communications, 12(1), 4452.

Zhang, Z., Ji, Z., He, J., Lu, Y., Tian, W., Zheng, C., ... & Sun, B. (2021). Guanine Nucleotide‐Binding Protein G (i) Subunit Alpha 2 Exacerbates NASH Progression by Regulating Peroxiredoxin 1–Related Inflammation and Lipophagy. Hepatology, 74(6), 3110-3126.

Hu, S., Dai, Y., Bai, S., Zhao, B., Wu, X., & Chen, Y. (2021). GNAI2 promotes proliferation and decreases apoptosis in rabbit melanocytes. Genes, 12(8), 1130.

Lu, Y., Xi, J., Zhang, Y., Chen, W., Zhang, F., Li, C., & Wang, Z. (2020). SNHG1 inhibits ox-LDL-induced inflammatory response and apoptosis of HUVECs via up-regulating GNAI2 and PCBP1. Frontiers in Pharmacology, 11, 703.

Li, Z. W., Sun, B., Gong, T., Guo, S., Zhang, J., Wang, J., ... & Chu, W. M. (2019). GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2. Gastroenterology, 156(8), 2297-2312.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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