Mouse Anti-GNB3 Recombinant Antibody (CBLG1-155) (CBMAB-G0577-LY)

Name: Mouse Anti-GNB3 Recombinant Antibody (CBLG1-155)
SKU: CBMAB-G0577-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLG1-155

Application

ELISA, ICC, WB

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Preservative

0.09% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

guanine nucleotide binding protein (G protein), beta polypeptide 3

Introduction

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]

Entrez Gene ID

2784

UniProt ID

P16520

Alternative Names

G Protein Subunit Beta 3; Transducin Beta Chain 3; Guanine Nucleotide Binding Protein (G Protein); Beta Polypeptide 3; Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Beta Subunit 3; Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-3; GTP-Binding Regulatory Protein Beta-3 Chain; Hypertension Associated Protein; G Protein; Beta-3 Subunit; CSNB1H;

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Biological Process

Cell volume homeostasis Source: ARUK-UCL
G protein-coupled receptor signaling pathway Source: GO_Central
Regulation of blood pressure Source: ProtInc
Regulation of cholesterol metabolic process Source: ARUK-UCL
Regulation of fat cell differentiation Source: ARUK-UCL
Regulation of gene expression Source: ARUK-UCL
Regulation of glucose metabolic process Source: ARUK-UCL
Regulation of hormone metabolic process Source: ARUK-UCL
Regulation of phospholipid metabolic process Source: ARUK-UCL
Regulation of triglyceride metabolic process Source: ARUK-UCL

Cellular Location

Cytosol; Extracellular exosome; Heterotrimeric G-protein complex; Cell body; Cytoplasm; Dendrite

Involvement in disease

Night blindness, congenital stationary, 1H (CSNB1H):
A form of congenital stationary night blindness, a non-progressive retinal disorder characterized by impaired night vision or in dim light, with good vision only on bright days. CSNB1H patients present with childhood-onset night blindness and middle age-onset photophobia, but have near-normal vision and do not exhibit nystagmus or high myopia. CSNB1H inheritance is autosomal recessive.

Peitz, T., Möhlendick, B., Siffert, W., Heinemann, F. M., Kribben, A., Eisenberger, U., & Friebus-Kardash, J. (2022). GNB3 c. 825C> T (rs5443) Polymorphism and Risk of Acute Cardiovascular Events after Renal Allograft Transplant. International Journal of Molecular Sciences, 23(17), 9783.

Purnell, P. R., Addicks, B. L., Zalzal, H. G., Shapiro, S., Wen, S., Ramadan, H. H., ... & Siderovski, D. P. (2019). Single nucleotide polymorphisms in chemosensory pathway genes GNB3, TAS2R19, and TAS2R38 are associated with chronic rhinosinusitis. International archives of allergy and immunology, 180(1), 72-78.

Eba, A., Raza, S. T., Abbas, M., Rizvi, S., Rajput, M., & Mahdi, F. (2019). Association of SDF1β (G801A) and GNB3 (C825T) polymorphisms with the incidence and severity of coronary artery disease. British Journal of Biomedical Science, 76(1), 49-51.

Sousa, A. C., Dos Reis, R. P., Pereira, A., Borges, S., Gouveia, S., Spínola, A., ... & Mendonça, M. I. (2018). The genetic variant C825T of the beta 3 subunit of G protein is associated with hypertension in a Portuguese population. Revista Portuguesa de Cardiologia (English Edition), 37(6), 499-507.

Jiang, D., Huang, D., Cai, W., Li, T., Wang, Y., Chen, H., ... & Ma, X. (2018). G protein beta 3 (GNβ3) C825T polymorphism and irritable bowel syndrome susceptibility: an updated meta-analysis based on eleven case-control studies. Oncotarget, 9(2), 2770.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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