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Mouse Anti-GNB3 Recombinant Antibody (M1-1-1D5) (CBMAB-G4133-LY)

This product is antibody recognizes GNB3. The antibody M1-1-1D5 immunoassay techniques such as: ELISA, IF, WB.
See all GNB3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
M1-1-1D5
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
guanine nucleotide binding protein (G protein), beta polypeptide 3
Introduction
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]
Entrez Gene ID
2784
UniProt ID
P16520
Alternative Names
G Protein Subunit Beta 3; Transducin Beta Chain 3; Guanine Nucleotide Binding Protein (G Protein); Beta Polypeptide 3; Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Beta Subunit 3; Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-3; GTP-Binding Regulatory Protein Beta-3 Chain; Hypertension Associated Protein; G Protein; Beta-3 Subunit; CSNB1H;
Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Biological Process
Cell volume homeostasis Source: ARUK-UCL
G protein-coupled receptor signaling pathway Source: GO_Central
Regulation of blood pressure Source: ProtInc
Regulation of cholesterol metabolic process Source: ARUK-UCL
Regulation of fat cell differentiation Source: ARUK-UCL
Regulation of gene expression Source: ARUK-UCL
Regulation of glucose metabolic process Source: ARUK-UCL
Regulation of hormone metabolic process Source: ARUK-UCL
Regulation of phospholipid metabolic process Source: ARUK-UCL
Regulation of triglyceride metabolic process Source: ARUK-UCL
Cellular Location
Cytosol; Extracellular exosome; Heterotrimeric G-protein complex; Cell body; Cytoplasm; Dendrite
Involvement in disease
Night blindness, congenital stationary, 1H (CSNB1H):
A form of congenital stationary night blindness, a non-progressive retinal disorder characterized by impaired night vision or in dim light, with good vision only on bright days. CSNB1H patients present with childhood-onset night blindness and middle age-onset photophobia, but have near-normal vision and do not exhibit nystagmus or high myopia. CSNB1H inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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