Mouse Anti-GNG5 Recombinant Antibody (CBLG1-1423) (CBMAB-G4154-LY)

This product is antibody recognizes GNG5. The antibody CBLG1-1423 immunoassay techniques such as: S-ELISA, ELISA, WB.
See all GNG5 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBLG1-1423

Antibody Isotype

IgG2a, κ

Application

S-ELISA, ELISA, WB

Basic Information

Immunogen

GNG5 (AAH03563, 1 a.a. ~ 68 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

G protein subunit gamma 5

Introduction

G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]

Entrez Gene ID

2787

UniProt ID

P63218

Alternative Names

G Protein Subunit Gamma 5; Guanine Nucleotide Binding Protein (G Protein); Gamma 5; GNGT5;

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Biological Process

G protein-coupled receptor signaling pathway Source: GO_Central
Signal transduction Source: UniProtKB

Cellular Location

Cell membrane

References

Wang, H., Yu, L., Cui, Y., & Huang, J. (2022). G Protein Subunit Gamma 5 Is a Prognostic Biomarker and Correlated with Immune Infiltrates in Hepatocellular Carcinoma. Disease Markers, 2022.

Yuan, Z., Ren, R., & Xu, Z. (2022). G protein subunit gamma 5 promotes the proliferation, metastasis and glycolysis of breast cancer cells through the Wnt/β-catenin pathway. Anti-Cancer Drugs, 33(10), 1004-1011.

Zhang, W., Liu, Z., Liu, B., Jiang, M., Yan, S., Han, X., ... & Lin, Z. (2021). GNG5 is a novel oncogene associated with cell migration, proliferation, and poor prognosis in glioma. Cancer cell international, 21(1), 1-20.

Ayo-Martin, A. C., Kyrousi, C., Di Giaimo, R., & Cappello, S. (2020). GNG5 controls the number of apical and basal progenitors and alters neuronal migration during cortical development. Frontiers in Molecular Biosciences, 7, 578137.

Shen, X. F., Cheng, Y., Dong, Q. R., & Zheng, M. Q. (2020). MicroRNA-675-3p regulates IL-1β-stimulated human chondrocyte apoptosis and cartilage degradation by targeting GNG5. Biochemical and Biophysical Research Communications, 527(2), 458-465.

Yang, B., Han, Z. Y., Wang, W. J., Ma, Y. B., & Chu, S. H. (2020). GNG5 is an unfavourable independent prognostic indicator of gliomas. Journal of Cellular and Molecular Medicine, 24(21), 12873-12878.

Hua, X., Chen, J., & Wu, L. (2019). Identification of candidate biomarkers associated with apoptosis in melanosis coli: GNG5, LPAR3, MAPK8, and PSMC6. Bioscience reports, 39(1).

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-GNG5 Recombinant Antibody (3B8)

Mouse Anti-GNG5 Recombinant Antibody (CBLG1-1421)

Rabbit Anti-GNG5 Recombinant Antibody (EG1341)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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