Rabbit Anti-GNG5 Recombinant Antibody (EG1341) (CBMAB-EN1619-LY)

The product is antibody recognizes GNG5. The antibody EG1341 immunoassay techniques such as: IF: 1:100~1:500 ELISA: 1:20000.
See all GNG5 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse, Rat

Clone

EG1341

Antibody Isotype

IgG

Application

IF: 1:100~1:500 ELISA: 1:20000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human GNG5.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

G protein subunit gamma 5

Introduction

G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules.

Entrez Gene ID

Human	2787
Mouse	14707
Rat	79218

UniProt ID

Human	P63218
Mouse	Q80SZ7
Rat	P63219

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Biological Process

G protein-coupled receptor signaling pathway Source: GO_Central
Signal transduction Source: UniProtKB

Cellular Location

Cell membrane

References

Wang, H., Yu, L., Cui, Y., & Huang, J. (2022). G Protein Subunit Gamma 5 Is a Prognostic Biomarker and Correlated with Immune Infiltrates in Hepatocellular Carcinoma. Disease Markers, 2022.

Yuan, Z., Ren, R., & Xu, Z. (2022). G protein subunit gamma 5 promotes the proliferation, metastasis and glycolysis of breast cancer cells through the Wnt/β-catenin pathway. Anti-Cancer Drugs, 33(10), 1004-1011.

Zhang, W., Liu, Z., Liu, B., Jiang, M., Yan, S., Han, X., ... & Lin, Z. (2021). GNG5 is a novel oncogene associated with cell migration, proliferation, and poor prognosis in glioma. Cancer cell international, 21(1), 1-20.

Ayo-Martin, A. C., Kyrousi, C., Di Giaimo, R., & Cappello, S. (2020). GNG5 controls the number of apical and basal progenitors and alters neuronal migration during cortical development. Frontiers in Molecular Biosciences, 7, 578137.

Shen, X. F., Cheng, Y., Dong, Q. R., & Zheng, M. Q. (2020). MicroRNA-675-3p regulates IL-1β-stimulated human chondrocyte apoptosis and cartilage degradation by targeting GNG5. Biochemical and Biophysical Research Communications, 527(2), 458-465.

Yang, B., Han, Z. Y., Wang, W. J., Ma, Y. B., & Chu, S. H. (2020). GNG5 is an unfavourable independent prognostic indicator of gliomas. Journal of Cellular and Molecular Medicine, 24(21), 12873-12878.

Hua, X., Chen, J., & Wu, L. (2019). Identification of candidate biomarkers associated with apoptosis in melanosis coli: GNG5, LPAR3, MAPK8, and PSMC6. Bioscience reports, 39(1).

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-GNG5 Recombinant Antibody (CBLG1-1423)

Mouse Anti-GNG5 Recombinant Antibody (CBLG1-1421)

Mouse Anti-GNG5 Recombinant Antibody (3B8)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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