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Mouse Anti-GNLY Recombinant Antibody (B-L38) (CBMAB-G4176-LY)

This product is antibody recognizes GNLY. The antibody B-L38 immunoassay techniques such as: ELISA, FC.
See all GNLY antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
B-L38
Antibody Isotype
IgG1
Application
ELISA, FC

Basic Information

Immunogen
Recombinant human Granulysin (NKG5 and LAG-2)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
granulysin
Introduction
The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Entrez Gene ID
10578
UniProt ID
P22749
Alternative Names
Granulysin; T-Lymphocyte Activation Gene 519; T-Cell Activation Protein 519; Lymphokine LAG-2; TLA519; LAG2;
Function
Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cellular defense response Source: UniProtKB
Defense response to bacterium Source: UniProtKB
Defense response to fungus Source: UniProtKB-KW
Killing of cells of other organism Source: UniProtKB
Cellular Location
Secreted. Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.
PTM
A 9 kDa form is produced by proteolytic processing of a 15 kDa protein.

Thakur, P., Sutiwisesak, R., Lu, Y. J., & Behar, S. M. (2022). Use of the Human Granulysin Transgenic Mice To Evaluate the Role of Granulysin Expression by CD8 T Cells in Immunity To Mycobacterium tuberculosis. Mbio, 13(6), e03020-22.

Milovanović, J., Todorović-Raković, N., Vujasinović, T., Greenman, J., Mandušić, V., & Radulovic, M. (2022). Can granulysin provide prognostic value in primary breast cancer?. Pathology-Research and Practice, 237, 154039.

Drvar, V., Ćurko‑Cofek, B., Karleuša, L., Aralica, M., Rogoznica, M., Kehler, T., ... & Laskarin, G. (2022). Granulysin expression and granulysin‑mediated apoptosis in the peripheral blood of osteoarthritis patients. Biomedical reports, 16(5), 1-10.

Chu, M. T., Wang, C. W., Chang, W. C., Chen, C. B., Chung, W. H., & Hung, S. I. (2021). Granulysin-based lymphocyte activation test for evaluating drug causality in antiepileptics-induced severe cutaneous adverse reactions. Journal of Investigative Dermatology, 141(6), 1461-1472.

Crespo, Â. C., Mulik, S., Dotiwala, F., Ansara, J. A., Santara, S. S., Ingersoll, K., ... & Lieberman, J. (2020). Decidual NK cells transfer granulysin to selectively kill bacteria in trophoblasts. Cell, 182(5), 1125-1139.

Hojo-Souza, N. S., de Azevedo, P. O., de Castro, J. T., Teixeira-Carvalho, A., Lieberman, J., Junqueira, C., & Gazzinelli, R. T. (2020). Contributions of IFN-γ and granulysin to the clearance of Plasmodium yoelii blood stage. PLoS Pathogens, 16(9), e1008840.

Dotiwala, F., & Lieberman, J. (2019). Granulysin: killer lymphocyte safeguard against microbes. Current opinion in immunology, 60, 19-29.

Vičić, M., Kaštelan, M., Tokmadžić, V. S., & Massari, L. P. (2019). Systemic and local increase of granulysin expression in cytotoxic lymphocytes in severe psoriasis. Acta dermato-venereologica, 99(12), 1136-1142.

Lettau, M., Dietz, M., Dohmen, K., Leippe, M., Kabelitz, D., & Janssen, O. (2019). Granulysin species segregate to different lysosome-related effector vesicles (LREV) and get mobilized by either classical or non-classical degranulation. Molecular immunology, 107, 44-53.

Gulic, T., Laskarin, G., Dominovic, M., Glavan Gacanin, L., Babarović, E., Rubesa, Z., ... & Rukavina, D. (2018). Granulysin‐mediated apoptosis of trophoblasts in blighted ovum and missed abortion. American journal of reproductive immunology, 80(3), e12978.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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