Mouse Anti-GORASP1 Recombinant Antibody (CBFYH-0425) (CBMAB-H1296-FY)

Name: Mouse Anti-GORASP1 Recombinant Antibody (CBFYH-0425)
SKU: CBMAB-H1296-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBFYH-0425

Application

WB, IHC, IF, FC

Immunogen

Full length human recombinant protein of human GORASP1 produced in HEK293T cell

Specificity

Human, Dog, Rat

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, PH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% Sodium azide

Concentration

0.96 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

golgi reassembly stacking protein 1

Introduction

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Alternative splicing results in multiple transcript variants of this gene.

Entrez Gene ID

Human	64689
Rat	56082
Dog	485594

UniProt ID

Human	Q9BQQ3
Rat	O35254
Dog	E2RJ37

Alternative Names

Golgi Reassembly Stacking Protein 1; Golgi Phosphoprotein 5; Golgi Reassembly-Stacking Protein Of 65 KDa; Golgi Reassembly Stacking Protein 1, 65kDa; Golgi Peripheral Membrane Protein P65; GRASP65

Function

Plays an important role in assembly and membrane stacking of the Golgi cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (PubMed:26363069).

Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis (By similarity).

Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344).

Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936).

Biological Process

Establishment of protein localization to plasma membrane Source: UniProtKB
Golgi organization Source: UniProtKB
Negative regulation of dendrite morphogenesis Source: UniProtKB
Protein N-linked glycosylation Source: Ensembl
Protein transport Source: UniProtKB-KW

Cellular Location

Cis-Golgi network membrane; Endoplasmic reticulum-Golgi intermediate compartment membrane

PTM

Phosphorylated by CDC2/B1 and PLK kinases during mitosis. Phosphorylation cycle correlates with the cisternal stacking cycle. Phosphorylation of the homodimer prevents the association of dimers into higher-order oligomers, leading to cisternal unstacking.By similarity
Target for caspase-3 cleavage during apoptosis. The cleavage contributes to Golgi fragmentation and occurs very early in the execution phase of apoptosis.By similarity
Myristoylated.By similarity

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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