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Mouse Anti-GPAT3 Recombinant Antibody (CBYJL-213) (CBMAB-L0299-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Glycerol-3-Phosphate Acyltransferase 3 (GPAT3). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all GPAT3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-213
Antibody Isotype
IgG2a, κ
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 3
Introduction
GPAT3 may transfer the acyl-group from acyl-coA to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. GPAT3 also transfers the acyl-group from acyl-coA to the sn-2 position of 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, or LPA), forming 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid, or PA).
Entrez Gene ID
84803
UniProt ID
Q53EU6
Alternative Names
Glycerol-3-Phosphate Acyltransferase 3; 1-Acyl-Sn-Glycerol-3-Phosphate O-Acyltransferase 10; 1-Acyl-Sn-Glycerol-3-Phosphate O-Acyltransferase 9; Acyl-CoA:Glycerol-3-Phosphate Acyltransferase 3; 1-Acylglycerol-3-Phosphate O-Acyltransferase 9; Lung Cancer Metastasis-Associated Protein 1; Lysophosphatidic Acid Acyltransferase Theta; 1-AGP Acyltransferase 9; LPAAT-Theta; EC 2.3.1.15; 1-AGPAT 9; AGPAT 10; AGPAT9; GPAT-3
Function
Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:17170135).

Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:19318427).
Biological Process
CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Glycerol-3-phosphate metabolic process Source: Ensembl
Phosphatidic acid biosynthetic process Source: Reactome
Regulation of TOR signaling Source: UniProtKB
Triglyceride biosynthetic process Source: UniProtKB
Cellular Location
Endoplasmic reticulum membrane

Fan, G., Li, Y., Zong, Y., Suo, X., Jia, Y., Gao, M., & Yang, X. (2023). GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway. Cell Death & Disease, 14(3), 208.

Song, J., Zhao, H., Zhang, L., Li, Z., Han, J., Zhou, C., ... & Yan, X. (2023). The heat shock transcription factor PtHSF1 mediates triacylglycerol and fucoxanthin synthesis by regulating the expression of GPAT3 and DXS in Phaeodactylum tricornutum. Plant and Cell Physiology, pcad023.

Ma, C., Sun, Y., Wang, J., Kang, L., & Jiang, Y. (2022). Identification of a promoter polymorphism affecting GPAT3 gene expression that is likely related to intramuscular fat content in pigs. Animal Biotechnology, 33(6), 1378-1381.

Tanigawa, K., Hayashi, Y., Hama, K., Yamashita, A., Yokoyama, K., Luo, Y., ... & Suzuki, K. (2021). Mycobacterium leprae promotes triacylglycerol de novo synthesis through induction of GPAT3 expression in human premonocytic THP-1 cells. PLoS One, 16(3), e0249184.

Sim, M. F., Persiani, E., Talukder, M., Uddin, M., Mcilroy, G. D., Roumane, A., ... & Rochford, J. J. (2020). Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation. Scientific Reports, 10(1), 1-14.

Gao, M., Liu, L., Wang, X., Mak, H. Y., Liu, G., & Yang, H. (2020). GPAT3 deficiency alleviates insulin resistance and hepatic steatosis in a mouse model of severe congenital generalized lipodystrophy. Human molecular genetics, 29(3), 432-443.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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