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Rat Anti-GPC2 Recombinant Antibody (15H66) (CBMAB-G4505-LY)

This product is antibody recognizes GPC2. The antibody 15H66 immunoassay techniques such as: IHC, WB.
See all GPC2 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
15H66
Antibody Isotype
IgG
Application
IHC, WB

Basic Information

Immunogen
Recombinant protein corresponding to mouse Glypican 2
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
lyophilized
Concentration
0.2 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glypican 2
Entrez Gene ID
71951
UniProt ID
Q8BKV1
Alternative Names
2410016G05Rik
Function
Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity).
Biological Process
Cell migration Source: GO_Central
Neuron differentiation Source: Ensembl
Positive regulation of neuron projection development Source: UniProtKB
Regulation of protein localization to membrane Source: GO_Central
Regulation of signal transduction Source: InterPro
Smoothened signaling pathway Source: GO_Central
Cellular Location
Cell membrane
Secreted glypican-2: Extracellular space

Brégère, C., Fisch, U., Halbeisen, F. S., Schneider, C., Dittmar, T., Stricker, S., ... & Guzman, R. (2023). Doublecortin and Glypican-2 concentrations in the cerebrospinal fluid from infants are developmentally downregulated. Plos one, 18(2), e0279343.

Li, N., & Ho, M. (2022). Development of Glypican-2 Targeting Single-Domain Antibody CAR T Cells for Neuroblastoma. In Single-Domain Antibodies: Methods and Protocols (pp. 451-468). New York, NY: Springer US.

Heitzeneder, S., Bosse, K. R., Zhu, Z., Zhelev, D., Majzner, R. G., Radosevich, M. T., ... & Mackall, C. L. (2022). GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity. Cancer Cell, 40(1), 53-69.

Tian, M., Cheuk, A. T., Wei, J. S., Abdelmaksoud, A., Chou, H. C., Milewski, D., ... & Khan, J. (2022). An optimized bicistronic chimeric antigen receptor against GPC2 or CD276 overcomes heterogeneous expression in neuroblastoma. The Journal of Clinical Investigation, 132(16).

Li, N., Torres, M. B., Spetz, M. R., Wang, R., Peng, L., Tian, M., ... & Ho, M. (2021). CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice. Cell Reports Medicine, 2(6), 100297.

Li, N., Spetz, M. R., Li, D., & Ho, M. (2021). Advances in immunotherapeutic targets for childhood cancers: A focus on glypican-2 and B7-H3. Pharmacology & therapeutics, 223, 107892.

Raman, S., Buongervino, S. N., Lane, M. V., Zhelev, D. V., Zhu, Z., Cui, H., ... & Bosse, K. R. (2021). A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope. Cell Reports Medicine, 2(7), 100344.

Foster, J., Griffin, C., Stern, A., Brimley, C., Buongervino, S., Storm, P., ... & Bosse, K. (2021). IMMU-16. Targeting Glypican 2 (Gpc2) On Pediatric Malignant Brain Tumors With Mrna Car T Cells. Neuro-Oncology, 23(Suppl 1), i30.

Zhang, T., Liu, Y., Ren, X., Wang, Z., & Wang, H. (2020). Glypican 2 regulates cell proliferation and metastasis in thyroid cancer cells. Molecular & Cellular Toxicology, 16, 203-209.

Heitzeneder, S., Bosse, K. R., Zhu, Z., Majzner, R. G., Theruvath, J., Xu, P., ... & Mackall, C. L. (2020). Abstract A09: Glypican-2 targeted CAR T cells designed to effectively eradicate endogenous site density solid tumors in the absence of toxicity. Cancer Research, 80(14_Supplement), A09-A09.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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