Sign in or Register
  • Home
  • GPC6
  • Mouse Anti-GPC6 Recombinant Antibody (CBLG1-1602)

Mouse Anti-GPC6 Recombinant Antibody (CBLG1-1602) (CBMAB-G4530-LY)

See all GPC6 antibodies
Go to compare Compare Online Inquiry
Datasheet
SDS
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBLG1-1602
Application
ELISA, FC
Immunogen
NS0-derived recombinant human Glypican 6 (aa24-527) Accession # NP_005699.ImmunogenType: Recombinant protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
lyophilized
Concentration
0.5 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
glypican 6
Introduction
The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Mutations in this gene are associated with omodysplasia 1. [provided by RefSeq, Nov 2016]
Entrez Gene ID
10082
UniProt ID
Q9Y625
Alternative Names
Glypican 6; Glypican Proteoglycan 6; Glypican-6; OMIMD1;
Function
Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity).

Enhances migration and invasion of cancer cells through WNT5A signaling.
Biological Process
Cell migration Source: UniProtKB
Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane Source: GO_Central
Regulation of presynapse assembly Source: GO_Central
Regulation of protein localization to membrane Source: GO_Central
Regulation of signal transduction Source: InterPro
Synaptic membrane adhesion Source: GO_Central
Cellular Location
Cell membrane
Secreted glypican-6: Extracellular space
Involvement in disease
Omodysplasia 1 (OMOD1):
The disease is caused by variants affecting the gene represented in this entry. Point mutations leading to protein truncation, as well as larger genomic rearrangements resulting in exon deletions, have been found in family segregating omodysplasia type 1. All mutations identified in individuals affected by omodysplasia could lead to the absence of a functional protein, the mutant RNAs being suspected to be nonsense-mediated mRNA decay (NMD) targets. Even if the mRNA escapes NMD and is translated, all mutations are expected to disrupt the three-dimensional protein structure and often to abolish multiple highly conserved cysteine residues.
A rare autosomal recessive skeletal dysplasia characterized by facial dysmorphism and severe congenital micromelia with shortening and distal tapering of the humeri and femora, to give a club-like appearance. Typical facial features include a prominent forehead, frontal bossing, short nose with a depressed broad bridge, short columella, anteverted nostrils, long philtrum, and small chin.

Colin-Pierre, C., Untereiner, V., Sockalingum, G. D., Ramont, L., & Brézillon, S. (2023). Investigation of Glypican-4 and-6 by Infrared Spectral Imaging during the Hair Growth Cycle. International Journal of Molecular Sciences, 24(5), 4291.

Shi, W., & Filmus, J. (2022). Glypican‐6 and Glypican‐4 stimulate embryonic stomach growth by regulating Hedgehog and noncanonical Wnt signaling. Developmental Dynamics, 251(12), 2015-2028.

Lehmkuhl, E. M., Loganathan, S., Alsop, E., Blythe, A. D., Kovalik, T., Mortimore, N. P., ... & Zarnescu, D. C. (2021). TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6. Acta neuropathologica communications, 9, 1-21.

Ozturk, F., Atici, A., & Barman, H. A. (2021). Can glypican-6 level predict ejection fraction decline after myocardial infarction?. Angiology, 72(6), 582-588.

Tenin, G., Crozier, A., Hentges, K. E., & Keavney, B. (2021). Glypican-6 deficiency causes dose-dependent conotruncal congenital heart malformations through abnormal remodelling of the endocardial cushions. Biorxiv, 2021-06.

Shi, W., Kaneiwa, T., Cydzik, M., Gariepy, J., & Filmus, J. (2020). Glypican-6 stimulates intestinal elongation by simultaneously regulating Hedgehog and non-canonical Wnt signaling. Matrix Biology, 88, 19-32.

Su, Y., Chen, Z., Du, H., Liu, R., Wang, W., Li, H., & Ning, B. (2019). Silencing miR‐21 induces polarization of astrocytes to the A2 phenotype and improves the formation of synapses by targeting Glypican 6 via the signal transducer and activator of transcription‐3 pathway after acute ischemic spinal cord injury. The FASEB Journal, 33(10), 10859-10871.

Li, Y., Li, M., Shats, I., Krahn, J. M., Flake, G. P., Umbach, D. M., ... & Li, L. (2019). Glypican 6 is a putative biomarker for metastatic progression of cutaneous melanoma. PLoS One, 14(6), e0218067.

Fan, C., Tu, C., Qi, P., Guo, C., Xiang, B., Zhou, M., ... & Zeng, Z. (2019). GPC6 promotes cell proliferation, migration, and invasion in nasopharyngeal carcinoma. Journal of Cancer, 10(17), 3926.

Hu, B., Xing, W., Li, F., Huang, Z., Zheng, W., Ji, D., ... & Yang, X. (2019). Association of glypican‐6 polymorphisms with lumbar disk herniation risk in the Han Chinese population. Molecular Genetics & Genomic Medicine, 7(7), e00747.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-GPC6 Recombinant Antibody (CBLG1-1602)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-GPC6 Recombinant Antibody (7H114) (CAT#: CBMAB-G4529-LY)

Mouse Anti-GPC6 Recombinant Antibody (CBFYH-0440) (CAT#: CBMAB-H0459-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry
Request bulk or custom quote Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry