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Rabbit Anti-GPR1 Recombinant Antibody (EG1353) (CBMAB-EN1632-LY)

The product is antibody recognizes GPR1. The antibody EG1353 immunoassay techniques such as: IF: 1:100~1:500 ELISA: 1:1000.
See all GPR1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG1353
Antibody Isotype
IgG
Application
IF: 1:100~1:500 ELISA: 1:1000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human GPR1.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G protein-coupled receptor 1
Entrez Gene ID
Human2825
Mouse241070
Rat25457
UniProt ID
HumanP46091
MouseQ8K087
RatP46090
Function
Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (PubMed:18165312, PubMed:27716822).

Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too (PubMed:27716822).

Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity).

(Microbial infection) Coreceptor for HIV-1.
Biological Process
Glucose homeostasis Source: UniProtKB
G protein-coupled receptor signaling pathway Source: ProtInc
Neuropeptide signaling pathway Source: GO_Central
Cellular Location
Cell membrane. Internalizes in presence of its ligand, TAFA1 (By similarity). Internalizes efficiently in response to RARRES2 (PubMed:27716822).
Topology
Extracellular: 1-41
Helical: 42-62
Cytoplasmic: 63-73
Helical: 74-94
Extracellular: 95-112
Helical: 113-133
Cytoplasmic: 134-154
Helical: 155-175
Extracellular: 176-210
Helical: 211-231
Cytoplasmic: 232-247
Helical: 248-268
Extracellular: 269-286
Helical: 287-307
Cytoplasmic: 308-355
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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