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Mouse Anti-GPR149 Recombinant Antibody (1D2) (CBMAB-G4633-LY)

This product is antibody recognizes GPR149. The antibody 1D2 immunoassay techniques such as: ELISA, IHC.
See all GPR149 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
1D2
Antibody Isotype
IgG2b, κ
Application
ELISA, IHC

Basic Information

Immunogen
Partial peptide of Human GPR149
Specificity
Human, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.25 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G Protein-Coupled Receptor 149
Introduction
This gene encodes a seven-transmembrane G protein coupled receptor (GPCR) class A family member. Although categorized as a class A GPCR, the encoded protein lacks the first two charged amino acids of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix of class A receptors which is important for efficient G protein-coupled signal transduction. Mice with a knockout of the orthologous gene are viable and have normal maturation of the ovarian follicle, but show enhanced fertility and ovulation. All GPCRs have a common structural architecture consisting of seven transmembrane alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptor, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]
Entrez Gene ID
Human344758
Rat192251
UniProt ID
HumanQ86SP6
RatQ924Y8
Alternative Names
G Protein-Coupled Receptor 149; PGR10; Probable G-Protein Coupled Receptor 149; G Protein-Coupled Receptor PGR10; G-Protein Coupled Receptor PGR10; IEDA; R35;
Function
Orphan receptor.
Biological Process
Antral ovarian follicle growth Source: Ensembl
Negative regulation of ovulation Source: Ensembl
Neuropeptide signaling pathway Source: GO_Central
Preantral ovarian follicle growth Source: Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 1-35
Helical: 36-56
Cytoplasmic: 57-69
Helical: 70-90
Extracellular: 91-109
Helical: 110-132
Cytoplasmic: 133-155
Helical: 156-176
Extracellular: 177-189
Helical: 190-210
Cytoplasmic: 211-310
Helical: 311-331
Extracellular: 332-342
Helical: 343-363
Cytoplasmic: 364-731
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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