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Mouse Anti-GPR17 Recombinant Antibody (3C10) (CBMAB-G4638-LY)

This product is antibody recognizes GPR17. The antibody 3C10 immunoassay techniques such as: ELISA, WB.
See all GPR17 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3C10
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa1-339 from human GPR17 (AAH31653) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G protein-coupled receptor 17
Entrez Gene ID
2840
UniProt ID
Q13304
Function
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.
Biological Process
G protein-coupled receptor signaling pathway Source: ProtInc
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: GO_Central
Positive regulation of Rho protein signal transduction Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-64
Helical: 65-85
Cytoplasmic: 86-92
Helical: 93-113
Extracellular: 114-133
Helical: 134-154
Cytoplasmic: 155-175
Helical: 176-196
Extracellular: 197-223
Helical: 224-244
Cytoplasmic: 245-260
Helical: 261-281
Extracellular: 282-308
Helical: 309-329
Cytoplasmic: 330-367

Liu, W., Yang, Y., Zeng, Z., Tian, Y., Wu, Q., Zhou, M., ... & Zhao, L. (2022). G protein-coupled receptor 17 restricts rabies virus replication via BAK-mediated apoptosis. Veterinary Microbiology, 265, 109326.

Daniele, S., Saporiti, S., Capaldi, S., Pietrobono, D., Russo, L., Guerrini, U., ... & Trincavelli, M. L. (2022). Functional Heterodimerization between the G Protein-Coupled Receptor GPR17 and the Chemokine Receptors 2 and 4: New Evidence. International Journal of Molecular Sciences, 24(1), 261.

Lin, K. N., Zhang, K., Zhao, W., Huang, S. Y., & Li, H. (2022). Insulin-like Growth Factor 1 Promotes Cell Proliferation by Downregulation of G-Protein-Coupled Receptor 17 Expression via PI3K/Akt/FoxO1 Signaling in SK-N-SH Cells. International Journal of Molecular Sciences, 23(3), 1513.

Marangon, D., Audano, M., Pedretti, S., Fumagalli, M., Mitro, N., Lecca, D., ... & Abbracchio, M. P. (2022). Rewiring of Glucose and Lipid Metabolism Induced by G Protein-Coupled Receptor 17 Silencing Enables the Transition of Oligodendrocyte Progenitors to Myelinating Cells. Cells, 11(15), 2369.

Liu, H., Xing, R., Ou, Z., Zhao, J., Hong, G., Zhao, T. J., ... & Chen, Y. (2021). G-protein-coupled receptor GPR17 inhibits glioma development by increasing polycomb repressive complex 1-mediated ROS production. Cell Death & Disease, 12(6), 610.

Doan, P., Nguyen, P., Murugesan, A., Subramanian, K., Konda Mani, S., Kalimuthu, V., ... & Kandhavelu, M. (2021). Targeting orphan G protein-coupled receptor 17 with T0 ligand impairs glioblastoma growth. Cancers, 13(15), 3773.

He, L., Yang, H., Feng, J., Wei, T., Huang, Y., Zhang, X., & Wang, Z. (2021). Knockdown of G protein-coupled receptor-17 (GPR17) facilitates the regeneration and repair of myelin sheath post-periventricular leukomalacia (PVL). Bioengineered, 12(1), 7314-7324.

Pillaiyar, T., Funke, M., Al-Hroub, H., Weyler, S., Ivanova, S., Schlegel, J., ... & Müller, C. E. (2020). Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory g protein-coupled receptors p2y2 and gpr17. European Journal of Medicinal Chemistry, 186, 111789.

Nyamoya, S., Leopold, P., Becker, B., Beyer, C., Hustadt, F., Schmitz, C., ... & Kipp, M. (2019). G-protein-coupled receptor Gpr17 expression in two multiple sclerosis remyelination models. Molecular neurobiology, 56, 1109-1123.

Lu, C., Dong, L., Zhou, H., Li, Q., Huang, G., & Liao, L. (2018). G-protein-coupled receptor Gpr17 regulates oligodendrocyte differentiation in response to lysolecithin-induced demyelination. Scientific reports, 8(1), 1-12.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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