Mouse Anti-GPR22 Recombinant Antibody (CBFYH-0455) (CBMAB-H0498-FY)

This product is mouse antibody that recognizes GPR22. The antibody CBFYH-0455 can be used for immunoassay techniques such as: FC.
See all GPR22 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYH-0455

Antibody Isotype

IgG2a

Application

Basic Information

Specificity

Human

Antibody Isotype

IgG2a

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.2 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

G protein-coupled receptor 22

Introduction

This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein.

Entrez Gene ID

2845

UniProt ID

Q99680

Alternative Names

G Protein-Coupled Receptor 22

Function

Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway (PubMed:18539757).

May be involved in ciliogenesis (By similarity).

Biological Process

Cell projection organization Source: UniProtKB-KW
G protein-coupled receptor signaling pathway Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-45
Helical: 46-66
Cytoplasmic: 67-85
Helical: 86-106
Extracellular: 107-115
Helical: 116-136
Cytoplasmic: 137-156
Helical: 157-177
Extracellular: 178-208
Helical: 209-229
Cytoplasmic: 230-315
Helical: 316-336
Extracellular: 337-349
Helical: 350-370
Cytoplasmic: 371-433

References

Watkins, L. R., & Orlandi, C. (2021). In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activity. British Journal of Pharmacology, 178(15), 2963-2975.

Atanes, P., Ashik, T., & Persaud, S. J. (2021). Obesity-induced changes in human islet G protein-coupled receptor expression: Implications for metabolic regulation. Pharmacology & Therapeutics, 228, 107928.

Guns, L. A., Lories, R., & Cailotto, F. (2018). G-proteïne-gekoppelde-receptor 22 (GPR22): een nieuw doelwit in osteoartrose?.

Egerod, K. L., Petersen, N., Timshel, P. N., Rekling, J. C., Wang, Y., Liu, Q., ... & Gautron, L. (2018). Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms. Molecular metabolism, 12, 62-75.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Rabbit Anti-GPR22 Recombinant Antibody (EG1397)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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