Rabbit Anti-GPR22 Recombinant Antibody (EG1397) (CBMAB-EN1676-LY)

The product is antibody recognizes GPR22. The antibody EG1397 immunoassay techniques such as: IF: 1:100~1:500 ELISA: 1:1000.
See all GPR22 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse

Clone

EG1397

Antibody Isotype

IgG

Application

IF: 1:100~1:500 ELISA: 1:1000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human GPR22.

Specificity

Human, Mouse

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

G protein-coupled receptor 22

Introduction

This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein.

Entrez Gene ID

Human	2845
Mouse	73010

UniProt ID

Human	Q99680
Mouse	Q8BZL4

Function

Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway (PubMed:18539757).

May be involved in ciliogenesis (By similarity).

Biological Process

Cell projection organization Source: UniProtKB-KW
G protein-coupled receptor signaling pathway Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-45
Helical: 46-66
Cytoplasmic: 67-85
Helical: 86-106
Extracellular: 107-115
Helical: 116-136
Cytoplasmic: 137-156
Helical: 157-177
Extracellular: 178-208
Helical: 209-229
Cytoplasmic: 230-315
Helical: 316-336
Extracellular: 337-349
Helical: 350-370
Cytoplasmic: 371-433

References

Watkins, L. R., & Orlandi, C. (2021). In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activity. British Journal of Pharmacology, 178(15), 2963-2975.

Atanes, P., Ashik, T., & Persaud, S. J. (2021). Obesity-induced changes in human islet G protein-coupled receptor expression: Implications for metabolic regulation. Pharmacology & Therapeutics, 228, 107928.

Guns, L. A., Lories, R., & Cailotto, F. (2018). G-proteïne-gekoppelde-receptor 22 (GPR22): een nieuw doelwit in osteoartrose?.

Egerod, K. L., Petersen, N., Timshel, P. N., Rekling, J. C., Wang, Y., Liu, Q., ... & Gautron, L. (2018). Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms. Molecular metabolism, 12, 62-75.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-GPR22 Recombinant Antibody (CBFYH-0455)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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