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Rabbit Anti-GPRC6A Recombinant Antibody (EG1416) (CBMAB-EN1695-LY)

The product is antibody recognizes GPRC6A. The antibody EG1416 immunoassay techniques such as: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:1000.
See all GPRC6A antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1416
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:1000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human GPC6A.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G Protein-Coupled Receptor Class C Group 6 Member A
Introduction
Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al., 2005 [PubMed 16199532]).[supplied by OMIM, Nov 2010]
Entrez Gene ID
222545
UniProt ID
Q5T6X5
Alternative Names
G Protein-Coupled Receptor Class C Group 6 Member A; G Protein-Coupled Receptor, Family C, Group 6, Member A; G-Protein Coupled Receptor GPCR33; G Protein-Coupled Receptor, Class C, Group 6, Member A; G-Protein Coupled Receptor Family C Group 6 Member A; Seven Transmembrane Helix Receptor;
Function
Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca2+ and Mg2+. Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids.
Biological Process
Response to amino acid Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 19-594
Helical: 595-615
Cytoplasmic: 616-631
Helical: 632-652
Extracellular: 653-669
Helical: 670-690
Cytoplasmic: 691-704
Helical: 705-725
Extracellular: 726-748
Helical: 749-769
Cytoplasmic: 770-782
Helical: 783-803
Extracellular: 804-810
Helical: 811-831
Cytoplasmic: 832-926
PTM
N-glycosylated.

Hou, Q., Huang, J., Xiong, X., Guo, Y., & Zhang, B. (2022). Role of nutrient-sensing receptor GPRC6A in regulating colonic group 3 innate lymphoid cells and inflamed mucosal healing. Journal of Crohn's and Colitis, 16(8), 1293-1305.

Zhang, M., Nie, X., Yuan, Y., Wang, Y., Ma, X., Yin, J., & Bao, Y. (2021). Osteocalcin alleviates nonalcoholic fatty liver disease in mice through GPRC6A. International Journal of Endocrinology, 2021, 1-10.

Pi, M., Nishimoto, S. K., & Darryl Quarles, L. (2021). Explaining divergent observations regarding osteocalcin/GPRC6A endocrine signaling. Endocrinology, 162(4), bqab011.

Pi, M., Xu, F., Ye, R., Nishimoto, S. K., Kesterson, R. A., Williams, R. W., ... & Quarles, L. D. (2020). Humanized GPRC6A KGKY is a gain-of-function polymorphism in mice. Scientific Reports, 10(1), 11143.

Jørgensen, C. V., & Bräuner‐Osborne, H. (2020). Pharmacology and physiological function of the orphan GPRC6A receptor. Basic & Clinical Pharmacology & Toxicology, 126, 77-87.

Pi, M., Xu, F., Ye, R., Nishimoto, S. K., Williams, R. W., Lu, L., & Darryl Quarles, L. (2020). Role of GPRC6A in regulating hepatic energy metabolism in mice. Scientific Reports, 10(1), 1-12.

Diaz‑Franco, M. C., Franco‑Diaz de Leon, R., & Villafan‑Bernal, J. R. (2019). Osteocalcin‑GPRC6A: An update of its clinical and biological multi‑organic interactions. Molecular Medicine Reports, 19(1), 15-22.

Jørgensen, C. V., Gasparini, S. J., Tu, J., Zhou, H., Seibel, M. J., & Bräuner-Osborne, H. (2019). Metabolic and skeletal homeostasis are maintained in full locus GPRC6A knockout mice. Scientific reports, 9(1), 5995.

Kalyvianaki, K., Panagiotopoulos, A. A., Malamos, P., Moustou, E., Tzardi, M., Stathopoulos, E. N., ... & Kampa, M. (2019). Membrane androgen receptors (OXER1, GPRC6A AND ZIP9) in prostate and breast cancer: A comparative study of their expression. Steroids, 142, 100-108.

Pi, M., Kapoor, K., Ye, R., Hwang, D. J., Miller, D. D., Smith, J. C., ... & Quarles, L. D. (2018). Computationally identified novel agonists for GPRC6A. PloS one, 13(4), e0195980.

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For research use only. Not intended for any clinical use.

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