GPRC6A

Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al., 2005 [PubMed 16199532]).[supplied by OMIM, Nov 2010]

Full Name

G Protein-Coupled Receptor Class C Group 6 Member A

Function

Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca2+ and Mg2+. Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids.

Biological Process

Response to amino acid Source: UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 19-594
Helical: 595-615
Cytoplasmic: 616-631
Helical: 632-652
Extracellular: 653-669
Helical: 670-690
Cytoplasmic: 691-704
Helical: 705-725
Extracellular: 726-748
Helical: 749-769
Cytoplasmic: 770-782
Helical: 783-803
Extracellular: 804-810
Helical: 811-831
Cytoplasmic: 832-926

PTM

N-glycosylated.