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Mouse Anti-GPX7 Recombinant Antibody (2704) (CBMAB-G4763-LY)

This product is antibody recognizes GPX7. The antibody 2704 immunoassay techniques such as: IHC, IHC-P, WB.
See all GPX7 antibodies
Published Data
Fig.1 Expression of GPX3, GPX7, and GSTM2 at the protein level following 5-Aza and TSA treatments.
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Fig.2 Immunohistochemical analyses of GPX7 proteins in primary BACs.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2704
Antibody Isotype
IgG
Application
IHC, IHC-P, WB

Basic Information

Immunogen
Human GPX7
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glutathione peroxidase 7
Entrez Gene ID
2882
UniProt ID
Q96SL4
Alternative Names
CL683; GPX6; GPx-7; GSHPx-7; NPGPx
Function
It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.
Biological Process
Cellular response to oxidative stress Source: Reactome
Cellular Location
Secreted
Involvement in disease
Barrett esophagus (BE):
A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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