Mouse Anti-GPX7 Recombinant Antibody (CBFYH-3473) (CBMAB-H4021-FY)

Name: Mouse Anti-GPX7 Recombinant Antibody (CBFYH-3473)
SKU: CBMAB-H4021-FY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYH-3473

Antibody Isotype

IgG

Application

WB, IHC-P

Basic Information

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

glutathione peroxidase 7

Introduction

GPX4 and GPX7 had a statistically significant over-expression in HCC tissues compared to cirrhotic counterparts used as non tumor tissues.

Entrez Gene ID

2882

UniProt ID

Q96SL4

Alternative Names

GPX6; CL683; GPx-7; NPGPx; GSHPx-7

Function

It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.

Biological Process

Cellular response to oxidative stress Source: Reactome

Cellular Location

Secreted

Involvement in disease

Barrett esophagus (BE):
A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.

More Infomation

References

Li, K., Jia, Q., Guo, J., Zhu, Z., Shao, M., Wang, J., ... & Miao, Y. (2022). The high chlorophyll fluorescence 244 (HCF244) Is potentially involved in glutathione peroxidase 7-regulated high light stress in Arabidopsis thaliana. Environmental and Experimental Botany, 195, 104767.

Hanousková, B., Vávrová, G., Ambrož, M., Boušová, I., Karlsen, T. A., Skálová, L., & Matoušková, P. (2021). MicroRNAs mediated regulation of glutathione peroxidase 7 expression and its changes during adipogenesis. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 1864(10), 194734.

Ferro, D., Franchi, N., Bakiu, R., Ballarin, L., & Santovito, G. (2018). Molecular characterization and metal induced gene expression of the novel glutathione peroxidase 7 from the chordate invertebrate Ciona robusta. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 205, 1-7.

Fang, J., Yang, J., Wu, X., Zhang, G., Li, T., Wang, X. E., ... & Wang, L. (2018). Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7. Aging Cell, 17(4), e12765.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-GPX7 Recombinant Antibody (2704)

Mouse Anti-GPX7 Recombinant Antibody (CBLG1-1690)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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