Mouse Anti-GRB10 Recombinant Antibody (EG1430) (CBMAB-EN1709-LY)

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Basic Information

Host Animal
Mouse
Clone
EG1430
Application
ELISA, IP, IF, WB, IHC-P
Immunogen
Amino acids 1-130 of human GRB10.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, gelatin
Preservative
Sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Growth Factor Receptor Bound Protein 10
Introduction
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
Entrez Gene ID
Human2887
Mouse14783
Rat498416
UniProt ID
HumanQ13322
MouseQ60760
RatP0CE43
Alternative Names
Growth Factor Receptor Bound Protein 10; Growth Factor Receptor-Bound Protein 10; Insulin Receptor-Binding Protein Grb-IR; GRB10 Adapter Protein; Maternally Expressed Gene 1; GRB10 Adaptor Protein; KIAA0207;

Dahiya, N., Kaur, M., Sharma, A., Singh, V., & Gupta, R. (2023, January). Network and Node Analysis of Growth factor receptor-binding protein 10: Insulin Signaling Pathway Regulator. In 2023 Third International Conference on Advances in Electrical, Computing, Communication and Sustainable Technologies (ICAECT) (pp. 1-4). IEEE.

Liu, H., He, Y., Bai, J., Zhang, C., Zhang, F., Yang, Y., ... & Xu, Y. (2023). Hypothalamic Grb10 enhances leptin signalling and promotes weight loss. Nature Metabolism, 1-18.

Yang, Y., Yao, H. J., Lin, W. J., Huang, S. C., Li, X. D., & He, F. Z. (2022). Real role of growth factor receptor-binding protein 10: Linking lipid metabolism to diabetes cardiovascular complications. World Journal of Clinical Cases, 10(35), 12875.

Chen, Y., Tang, M., Xiong, J., Gao, Q., Cao, W., & Huang, J. (2022). GRB10 is a novel oncogene associated with cell proliferation and prognosis in glioma. Cancer Cell International, 22(1), 1-13.

Cai, Z., Liu, F., Yang, Y., Li, D., Hu, S., Song, L., ... & Zhang, J. (2022). GRB10 regulates β-cell mass by inhibiting β-cell proliferation and stimulating β-cell dedifferentiation. Journal of Genetics and Genomics, 49(3), 208-216.

Wang, D., Ming, X., Xu, J., & Xiao, Y. (2021). Circ_0009910 shuttled by exosomes regulates proliferation, cell cycle and apoptosis of acute myeloid leukemia cells by regulating miR‐5195‐3p/GRB10 axis. Hematological Oncology, 39(3), 390-400.

Edick, A. M., Auclair, O., & Burgos, S. A. (2020). Role of Grb10 in mTORC1-dependent regulation of insulin signaling and action in human skeletal muscle cells. American Journal of Physiology-Endocrinology and Metabolism, 318(2), E173-E183.

Khan, M. I., Al Johani, A., Hamid, A., Ateeq, B., Manzar, N., Adhami, V. M., ... & Mukhtar, H. (2019). Proproliferative function of adaptor protein GRB10 in prostate carcinoma. The FASEB Journal, 33(3), 3198.

He, Z. Y., Wang, H. Y., Zhou, X., Liang, X. Y., Yan, B., Wang, R., ... & Wang, Y. L. (2018). Evaluation of vitrification protocol of mouse ovarian tissue by effect of DNA methyltransferase-1 and paternal imprinted growth factor receptor-binding protein 10 on signaling pathways. Cryobiology, 80, 89-95.

Hao, J., Ci, X., Xue, H., Wu, R., Dong, X., Choi, S. Y. C., ... & Wang, Y. (2018). Patient-derived hormone-naive prostate cancer xenograft models reveal growth factor receptor bound protein 10 as an androgen receptor-repressed gene driving the development of castration-resistant prostate cancer. European urology, 73(6), 949-960.

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For research use only. Not intended for any clinical use.

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