Sign in or Register   Sign in or Register
  |  

Mouse Anti-GREM2 Recombinant Antibody (CBFYH-0473) (CBMAB-H1345-FY)

This product is mouse antibody that recognizes GREM2. The antibody CBFYH-0473 can be used for immunoassay techniques such as: ELISA, ELISA(Cap).
See all GREM2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0473
Antibody Isotype
IgG2a, κ
Application
ELISA, ELISA(Cap)

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis)
Introduction
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation.
Entrez Gene ID
64388
UniProt ID
Q9H772
Alternative Names
Gremlin 2, DAN Family BMP Antagonist; Protein Related To DAN And Cerberus; Cysteine Knot Superfamily 1, BMP Antagonist 2; DAN Domain Family Member 3; CKTSF1B2; DAND3; PRDC
Function
Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells.
Biological Process
Animal organ morphogenesis Source: GO_Central
Cytokine-mediated signaling pathway Source: UniProtKB
Embryonic body morphogenesis Source: UniProtKB
Regulation of cytokine activity Source: UniProtKB
Sequestering of BMP from receptor via BMP binding Source: GO_Central
Cellular Location
Secreted
Involvement in disease
Tooth agenesis, selective, 9 (STHAG9):
A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). STHAG9 inheritance is autosomal dominant.
PTM
N-glycosylated.

Liu, W., Li, D., Yang, M., Wang, L., Xu, Y., Chen, N., ... & Wang, J. (2022). GREM2 is associated with human central obesity and inhibits visceral preadipocyte browning. EBioMedicine, 78, 103969.

Zhang, Z., & Zhu, X. (2022). MiR-103a-3p Contributes to the Progression of Colorectal Cancer by Regulating GREM2 Expression. Yonsei Medical Journal, 63(6), 520.

Huang, X., Jie, S., Li, W., Li, H., Ni, J., & Liu, C. (2022). miR-122–5p targets GREM2 to protect against glucocorticoid-induced endothelial damage through the BMP signaling pathway. Molecular and Cellular Endocrinology, 544, 111541.

Zhou, X., Xu, W., Wang, Y., Zhang, H., Zhang, L., Li, C., ... & Luo, D. (2021). LncRNA DNM3OS regulates GREM2 via miR-127-5p to suppress early chondrogenic differentiation of rat mesenchymal stem cells under hypoxic conditions. Cellular & Molecular Biology Letters, 26(1), 1-17.

Ma, G., Chen, J., Wei, T., Wang, J., & Chen, W. (2021). Inhibiting roles of FOXA2 in liver cancer cell migration and invasion by transcriptionally suppressing microRNA-103a-3p and activating the GREM2/LATS2/YAP axis. Cytotechnology, 73(4), 523-537.

Shan, G., Gu, J., Zhou, D., Li, L., Cheng, W., Wang, Y., ... & Wang, X. (2020). Cancer-associated fibroblast-secreted exosomal miR-423-5p promotes chemotherapy resistance in prostate cancer by targeting GREM2 through the TGF-β signaling pathway. Experimental & Molecular Medicine, 52(11), 1809-1822.

Wen, H., Kumar, V., Mishra, A., Song, S., Aslam, R., Hussain, A., ... & Singhal, P. C. (2019). Grem2 mediates podocyte apoptosis in high glucose milieu. Biochimie, 160, 113-121.

Mostowska, A., Biedziak, B., Zadurska, M., Bogdanowicz, A., Olszewska, A., Cieślińska, K., ... & Jagodziński, P. P. (2018). GREM2 nucleotide variants and the risk of tooth agenesis. Oral Diseases, 24(4), 591-599.

Magruder, S., Carter, E., Williams, M. A., English, J., Akyalcin, S., & Letra, A. (2018). Further evidence for the role of WNT 10A, WNT 10B and GREM 2 as candidate genes for isolated tooth agenesis. Orthodontics & Craniofacial Research, 21(4), 258-263.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-GREM2 Recombinant Antibody (CBFYH-0473)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare