Mouse Anti-GRHPR Recombinant Antibody (CBFYH-0477) (CBMAB-H1349-FY)

Name: Mouse Anti-GRHPR Recombinant Antibody (CBFYH-0477)
SKU: CBMAB-H1349-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-0477

Application

FC, WB

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, PH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% Sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Glyoxylate And Hydroxypyruvate Reductase

Introduction

This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene.

Entrez Gene ID

9380

UniProt ID

Q9UBQ7

Alternative Names

Glyoxylate And Hydroxypyruvate Reductase; Glyoxylate Reductase And Hydroxypyruvate Reductase; Glyoxylate Reductase/Hydroxypyruvate Reductase; GLXR; Primary Hyperoxaluria Type 2; Glycerate-2-Dehydrogenase

Function

Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.

Biological Process

Carboxylic acid metabolic process Source: Reactome
Dicarboxylic acid metabolic process Source: Ensembl
Excretion Source: UniProtKB
Glyoxylate metabolic process Source: UniProtKB

Cellular Location

Cytosol; Extracellular exosome; Peroxisomal matrix; Catalytic complex; Cytoplasm

Involvement in disease

Hyperoxaluria primary 2 (HP2):
A disorder characterized by elevated urinary excretion of oxalate and L-glycerate, progressive tissue accumulation of insoluble calcium oxalate, nephrolithiasis, nephrocalcinosis, and end-stage renal disease.

Chatterjee, A., Sarkar, K., Bank, S., Saraf, S., wakle, D., pal, D. K., ... & Das, M. (2022). Whole Exome Sequencing (WES) identifies Homozygous mutation in g. 37429732G> A in GRHPR gene is responsible for early onset of nephrolithiasis in the population of West Bengal, India. medRxiv, 2022-01.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

GRHPR Matched Antibody Pair (499) (CAT#: APMAB-499LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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