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GRHPR

This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008]

Full Name

Glyoxylate And Hydroxypyruvate Reductase

Function

Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.

Biological Process

Carboxylic acid metabolic process Source: Reactome
Dicarboxylic acid metabolic process Source: Ensembl
Excretion Source: UniProtKB
Glyoxylate metabolic process Source: UniProtKB

Cellular Location

Cytosol; Extracellular exosome; Peroxisomal matrix; Catalytic complex; Cytoplasm

Involvement in disease

Hyperoxaluria primary 2 (HP2):
A disorder characterized by elevated urinary excretion of oxalate and L-glycerate, progressive tissue accumulation of insoluble calcium oxalate, nephrolithiasis, nephrocalcinosis, and end-stage renal disease.

Anti-GRHPR antibodies

Mouse Anti-GRHPR Recombinant Antibody (CBFYH-0476) (CBMAB-H1348-FY)

SDS

Target: GRHPR

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYH-0476

Application*: WB, F

Mouse Anti-GRHPR Recombinant Antibody (CBFYH-0477) (CBMAB-H1349-FY)

SDS

Target: GRHPR

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYH-0477

Application*: F, WB

Mouse Anti-GRHPR Recombinant Antibody (CBLG1-226) (CBMAB-G0769-LY)

SDS

Target: GRHPR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-226

Application*: E, WB

Mouse Anti-GRHPR Recombinant Antibody (10A3) (CBMAB-G4850-LY)

SDS

Target: GRHPR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10A3

Application*: F

Mouse Anti-GRHPR Recombinant Antibody (10C402) (CBMAB-G4851-LY)

SDS

Target: GRHPR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10C402

Application*: E, WB

Mouse Anti-GRHPR Recombinant Antibody (CBLG1-2946) (CBMAB-G4860-LY)

SDS

Target: GRHPR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-2946

Application*: WB

Mouse Anti-GRHPR Recombinant Antibody (CBLG1-2949) (CBMAB-G4863-LY)

SDS

Target: GRHPR

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBLG1-2949

Application*: WB

Mouse Anti-GRHPR Recombinant Antibody (CBLG1-1724) (CBMAB-G4866-LY)

SDS

Target: GRHPR

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBLG1-1724

Application*: SE, E, WB

Mouse Anti-GRHPR Recombinant Antibody (CBLG1-1725) (CBMAB-G4867-LY)

SDS

Target: GRHPR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-1725

Application*: WB

Mouse Anti-GRHPR Recombinant Antibody (CBLG1-1726) (CBMAB-G4868-LY)

SDS

Target: GRHPR

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBLG1-1726

Application*: E, EC, WB

Mouse Anti-GRHPR Recombinant Antibody (CBFYH-0475) (CBMAB-H1347-FY)

SDS

Target: GRHPR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYH-0475

Application*: WB, IH, F

Mouse Anti-GRHPR Recombinant Antibody (2H4) (CBMAB-G4854-LY)

SDS

Target: GRHPR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2H4

Application*: WB

Mouse Anti-GRHPR Recombinant Antibody (4B6) (CBMAB-G4855-LY)

SDS

Target: GRHPR

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 4B6

Application*: F

Mouse Anti-GRHPR Recombinant Antibody (4H2) (CBMAB-G4857-LY)

SDS

Target: GRHPR

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 4H2

Application*: F

Mouse Anti-GRHPR Recombinant Antibody (9G2) (CBMAB-G4859-LY)

SDS

Target: GRHPR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 9G2

Application*: F

GRHPR Matched Antibody Pair (499) (APMAB-499LY)

SDS

Target: GRHPR

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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