GRHPR

This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008]
Full Name
Glyoxylate And Hydroxypyruvate Reductase
Function
Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.
Biological Process
Carboxylic acid metabolic process Source: Reactome
Dicarboxylic acid metabolic process Source: Ensembl
Excretion Source: UniProtKB
Glyoxylate metabolic process Source: UniProtKB
Cellular Location
Cytosol; Extracellular exosome; Peroxisomal matrix; Catalytic complex; Cytoplasm
Involvement in disease
Hyperoxaluria primary 2 (HP2):
A disorder characterized by elevated urinary excretion of oxalate and L-glycerate, progressive tissue accumulation of insoluble calcium oxalate, nephrolithiasis, nephrocalcinosis, and end-stage renal disease.
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Anti-GRHPR antibodies

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Mouse Anti-GRHPR Recombinant Antibody (CBLG1-1726) (CBMAB-G4868-LY)

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Target: GRHPR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-1726
Application*: E, EC, WB
Datasheet SDS

Mouse Anti-GRHPR Recombinant Antibody (CBLG1-1725) (CBMAB-G4867-LY)

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Target: GRHPR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1725
Application*: WB
Datasheet SDS

Mouse Anti-GRHPR Recombinant Antibody (CBLG1-1724) (CBMAB-G4866-LY)

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Target: GRHPR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-1724
Application*: SE, E, WB
Datasheet SDS

Mouse Anti-GRHPR Recombinant Antibody (CBLG1-2949) (CBMAB-G4863-LY)

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Target: GRHPR
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-2949
Application*: WB
Datasheet SDS

Mouse Anti-GRHPR Recombinant Antibody (CBLG1-2946) (CBMAB-G4860-LY)

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Target: GRHPR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2946
Application*: WB
Datasheet SDS

Mouse Anti-GRHPR Recombinant Antibody (9G2) (CBMAB-G4859-LY)

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Target: GRHPR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9G2
Application*: F
Datasheet SDS

Mouse Anti-GRHPR Recombinant Antibody (4H2) (CBMAB-G4857-LY)

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Target: GRHPR
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4H2
Application*: F
Datasheet SDS

Mouse Anti-GRHPR Recombinant Antibody (4B6) (CBMAB-G4855-LY)

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Target: GRHPR
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4B6
Application*: F
Datasheet SDS

Mouse Anti-GRHPR Recombinant Antibody (2H4) (CBMAB-G4854-LY)

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Target: GRHPR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2H4
Application*: WB
Datasheet SDS

Mouse Anti-GRHPR Recombinant Antibody (10C402) (CBMAB-G4851-LY)

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Target: GRHPR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10C402
Application*: E, WB
Datasheet SDS

Mouse Anti-GRHPR Recombinant Antibody (10A3) (CBMAB-G4850-LY)

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Target: GRHPR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10A3
Application*: F
Datasheet SDS

Mouse Anti-GRHPR Recombinant Antibody (CBLG1-226) (CBMAB-G0769-LY)

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Target: GRHPR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-226
Application*: E, WB
Datasheet SDS

Mouse Anti-GRHPR Recombinant Antibody (CBFYH-0477) (CBMAB-H1349-FY)

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Target: GRHPR
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-0477
Application*: F, WB
Datasheet SDS

Mouse Anti-GRHPR Recombinant Antibody (CBFYH-0476) (CBMAB-H1348-FY)

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Target: GRHPR
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-0476
Application*: WB, F
Datasheet SDS

Mouse Anti-GRHPR Recombinant Antibody (CBFYH-0475) (CBMAB-H1347-FY)

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Target: GRHPR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0475
Application*: WB, IH, F
Datasheet SDS

GRHPR Matched Antibody Pair (499) (APMAB-499LY)

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Target: GRHPR
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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