Mouse Anti-GRIK1 Recombinant Antibody (4F5) (CBMAB-G4928-LY)

Name: Mouse Anti-GRIK1 Recombinant Antibody (4F5)
SKU: CBMAB-G4928-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4F5

Application

ELISA, IHC, ICC/IF, RIA

Immunogen

Recombinant fusion protein TrpE-GluR5

Specificity

Human, Rat

Antibody Isotype

IgM

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

glutamate receptor, ionotropic, kainate 1

Introduction

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	2897
Rat	29559

UniProt ID

Human	P39086
Rat	P22756

Function

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.

Biological Process

Central nervous system development Source: ProtInc
Chemical synaptic transmission Source: ProtInc
Glutamate receptor signaling pathway Source: ProtInc
Modulation of chemical synaptic transmission Source: GO_Central
Nervous system development Source: ProtInc
Regulation of synaptic transmission, glutamatergic Source: UniProtKB
Synaptic transmission, glutamatergic Source: GO_Central

Cellular Location

Cell membrane; Postsynaptic cell membrane

Topology

Extracellular: 31-576
Helical: 577-597
Cytoplasmic: 598-653
Helical: 654-674
Extracellular: 675-834
Helical: 835-855
Cytoplasmic: 856-918

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-GRIK1 Recombinant Antibody (CBLG1-1746) (CAT#: CBMAB-G4929-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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