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  • Rabbit Anti-GRIN2D Recombinant Antibody (EG1441)

Rabbit Anti-GRIN2D Recombinant Antibody (EG1441) (CBMAB-EN1721-LY)

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Datasheet
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Basic Information

Host Animal
Rabbit
Clone
EG1441
Application
WB: 1:500~1:1000 ELISA: 1:40000
Immunogen
The antibody was produced against synthesized peptide derived from internal of human GRIN2D.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
glutamate ionotropic receptor NMDA type subunit 2D
Introduction
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).
Entrez Gene ID
Human2906
Mouse14814
Rat24412
UniProt ID
HumanO15399
MouseQ03391
RatQ62645
Alternative Names
EB11; NR2D; DEE46; EIEE46; GluN2D; NMDAR2D
Function
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed:9489750, PubMed:27616483, PubMed:26875626, PubMed:28126851).

Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:9489750).
Biological Process
Adult locomotory behavior Source: Ensembl
Brain development Source: ARUK-UCL
Calcium ion transmembrane import into cytosol Source: UniProtKB
Excitatory chemical synaptic transmission Source: ARUK-UCL
Excitatory postsynaptic potential Source: GO_Central
Long-term synaptic potentiation Source: GO_Central
Regulation of sensory perception of pain Source: Ensembl
Regulation of synaptic plasticity Source: ARUK-UCL
Startle response Source: Ensembl
Cellular Location
Cell membrane; Postsynaptic cell membrane
Involvement in disease
Developmental and epileptic encephalopathy 46 (DEE46):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent.
Topology
Extracellular: 28-584
Helical: 585-603
Cytoplasmic: 604-630
Discontinuously helical: 631-650
Cytoplasmic: 651-657
Helical: 658-673
Extracellular: 674-844
Helical: 845-864
Cytoplasmic: 865-1336

Li, J., Zhou, Y., Su, T., & Xu, S. (2023). Perampanel therapy for intractable GRIN2D-related developmental and epileptic encephalopathy: A case report and literature review. Brain and Development, 45(4), 237-243.

Chen, Z., Song, Y., Li, P., & Gao, W. (2023). GRIN2D knockdown suppresses the progression of lung adenocarcinoma by regulating the E2F signalling pathway. Cellular Signalling, 107, 110685.

Platzer, K., Krey, I., & Lemke, J. R. (2022). GRIN2D-Related Developmental and Epileptic Encephalopathy. GeneReviews®[Internet].

Neumann, A., Ohlei, O., Küçükali, F., Bos, I. J., Vos, S., Prokopenko, D., ... & EMIF-AD & ADNI study group. (2022). Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioning. medRxiv, 2022-08.

Li, Q., Gu, Z., Tan, Q., Ren, L., & Chen, S. (2022). MicroRNA-129-1-3p Represses the Progression of Triple-Negative Breast Cancer by Targeting the GRIN2D Gene. BioMed Research International, 2022.

Hausman-Kedem, M., Menascu, S., Greenstein, Y., & Fattal-Valevski, A. (2020). Immunotherapy for GRIN2A and GRIN2D-related epileptic encephalopathy. Epilepsy Research, 163, 106325.

Camp, C. R., & Yuan, H. (2020). GRIN2D/GluN2D NMDA receptor: Unique features and its contribution to pediatric developmental and epileptic encephalopathy. European Journal of Paediatric Neurology, 24, 89-99.

Li, Q., Qin, M., Tan, Q., Li, T., Gu, Z., Huang, P., & Ren, L. (2020). MicroRNA‐129‐1‐3p protects cardiomyocytes from pirarubicin‐induced apoptosis by down‐regulating the GRIN2D‐mediated Ca2+ signalling pathway. Journal of Cellular and Molecular Medicine, 24(3), 2260-2271.

XiangWei, W., Kannan, V., Xu, Y., Kosobucki, G. J., Schulien, A. J., Kusumoto, H., ... & Jiang, Y. (2019). Heterogeneous clinical and functional features of GRIN2D-related developmental and epileptic encephalopathy. Brain, 142(10), 3009-3027.

Tsuchida, N., Hamada, K., Shiina, M., Kato, M., Kobayashi, Y., Tohyama, J., ... & Matsumoto, N. (2018). GRIN2D variants in three cases of developmental and epileptic encephalopathy. Clinical genetics, 94(6), 538-547.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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