GRIN2D

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).

Full Name

glutamate ionotropic receptor NMDA type subunit 2D

Function

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed:9489750, PubMed:27616483, PubMed:26875626, PubMed:28126851).

Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:9489750).

Biological Process

Adult locomotory behavior Source: Ensembl
Brain development Source: ARUK-UCL
Calcium ion transmembrane import into cytosol Source: UniProtKB
Excitatory chemical synaptic transmission Source: ARUK-UCL
Excitatory postsynaptic potential Source: GO_Central
Long-term synaptic potentiation Source: GO_Central
Regulation of sensory perception of pain Source: Ensembl
Regulation of synaptic plasticity Source: ARUK-UCL
Startle response Source: Ensembl

Cellular Location

Cell membrane; Postsynaptic cell membrane

Involvement in disease

Developmental and epileptic encephalopathy 46 (DEE46):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent.

Topology

Extracellular: 28-584
Helical: 585-603
Cytoplasmic: 604-630
Discontinuously helical: 631-650
Cytoplasmic: 651-657
Helical: 658-673
Extracellular: 674-844
Helical: 845-864
Cytoplasmic: 865-1336