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Mouse Anti-GRK7 (AA 1-100) Recombinant Antibody (CBFYH-0492) (CBMAB-H1361-FY)

This product is mouse antibody that recognizes GRK7. The antibody CBFYH-0492 can be used for immunoassay techniques such as: ELISA.
See all GRK7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0492
Antibody Isotype
IgG2b, κ
Application
ELISA

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: MVDMGALDNL IANTAYLQAR KPSDCDSKEL QRRRRSLALP GLQGCAELRQ KLSLNFHSLC EQQPIGRRLF RDFLATVPTF RKAATFLEDV QNWELAEEGP
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-100

Target

Full Name
G Protein-Coupled Receptor Kinase 7
Introduction
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation.
Entrez Gene ID
131890
UniProt ID
Q8WTQ7
Alternative Names
G Protein-Coupled Receptor Kinase 7; G Protein-Coupled Receptor Kinase GRK7; GPRK7; Rhodopsin Kinase; EC 2.7.11.16; EC 2.7.11.14; EC 2.7.1
Function
Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).
Biological Process
Protein autophosphorylation Source: UniProtKB
Protein phosphorylation Source: GO_Central
Regulation of rhodopsin mediated signaling pathway Source: Reactome
Regulation of signal transduction Source: GO_Central
Signal transduction Source: InterPro
Visual perception Source: UniProtKB-KW
Cellular Location
Membrane
PTM
Autophosphorylated in vitro at Ser-490. Phosphorylation at Ser-36 is regulated by light and activated by cAMP.

Jiang, H., Galtes, D., Wang, J., & Rockman, H. A. (2022). G protein-coupled receptor signaling: transducers and effectors. American Journal of Physiology-Cell Physiology, 323(3), C731-C748.

Sulon, S. M., & Benovic, J. L. (2021). Targeting G protein–coupled receptor kinases to G protein–coupled receptors. Current opinion in endocrine and metabolic research, 16, 56-65.

Ahrens, N., Elbers, D., Greb, H., Janssen-Bienhold, U., & Koch, K. W. (2021). Interaction of G protein-coupled receptor kinases and recoverin isoforms is determined by localization in zebrafish photoreceptors. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1868(4), 118946.

Benovic, J. L. (2021). Historical perspective of the G protein-coupled receptor kinase family. Cells, 10(3), 555.

Kolesnikov, A. V., Chrispell, J. D., Osawa, S., Kefalov, V. J., & Weiss, E. R. (2020). Phosphorylation at Serine 21 in G protein-coupled receptor kinase 1 (GRK1) is required for normal kinetics of dark adaption in rod but not cone photoreceptors. FASEB journal: official publication of the Federation of American Societies for Experimental Biology, 34(2), 2677.

Pfleger, J., Gresham, K., & Koch, W. J. (2019). G protein-coupled receptor kinases as therapeutic targets in the heart. Nature Reviews Cardiology, 16(10), 612-622.

Komolov, K. E., & Benovic, J. L. (2018). G protein-coupled receptor kinases: Past, present and future. Cellular signalling, 41, 17-24.

Yu, S., Sun, L., Jiao, Y., & Lee, L. T. O. (2018). The role of G protein-coupled receptor kinases in cancer. International journal of biological sciences, 14(2), 189.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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