GRK7

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008]
Full Name
G Protein-Coupled Receptor Kinase 7
Function
Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).
Biological Process
Protein autophosphorylation Source: UniProtKB
Protein phosphorylation Source: GO_Central
Regulation of rhodopsin mediated signaling pathway Source: Reactome
Regulation of signal transduction Source: GO_Central
Signal transduction Source: InterPro
Visual perception Source: UniProtKB-KW
Cellular Location
Membrane
PTM
Autophosphorylated in vitro at Ser-490. Phosphorylation at Ser-36 is regulated by light and activated by cAMP.
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Anti-GRK7 antibodies

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Rabbit Anti-GRK7 Recombinant Antibody (EG1448) (CBMAB-EN1729-LY)

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Target: GRK7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1448
Application*: WB: 1:500~1:1000 ELISA: 1:5000
Datasheet SDS

Mouse Anti-GRK7 Recombinant Antibody (4C4) (CBMAB-A3592-LY)

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Target: GRK7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4C4
Application*: E, E
Datasheet SDS

Mouse Anti-GRK7 Recombinant Antibody (CBLG1-3209) (CBMAB-G5025-LY)

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Target: GRK7
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-3209
Application*: WB
Datasheet SDS

Mouse Anti-GRK7 Recombinant Antibody (496831) (CBMAB-G5023-LY)

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Target: GRK7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 496831
Application*: WB
Datasheet SDS

Mouse Anti-GRK7 (AA 1-100) Recombinant Antibody (CBFYH-0492) (CBMAB-H1361-FY)

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Target: GRK7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYH-0492
Application*: E
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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