GRK7

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008]

Full Name

G Protein-Coupled Receptor Kinase 7

Function

Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).

Biological Process

Protein autophosphorylation Source: UniProtKB
Protein phosphorylation Source: GO_Central
Regulation of rhodopsin mediated signaling pathway Source: Reactome
Regulation of signal transduction Source: GO_Central
Signal transduction Source: InterPro
Visual perception Source: UniProtKB-KW

Cellular Location

Membrane

PTM

Autophosphorylated in vitro at Ser-490. Phosphorylation at Ser-36 is regulated by light and activated by cAMP.

Anti-GRK7 antibodies

Mouse Anti-GRK7 (AA 1-100) Recombinant Antibody (CBFYH-0492) (CBMAB-H1361-FY)

Datasheet

SDS

Target: GRK7

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYH-0492

Application*: E

Mouse Anti-GRK7 Recombinant Antibody (496831) (CBMAB-G5023-LY)

Datasheet

SDS

Target: GRK7

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 496831

Application*: WB

Mouse Anti-GRK7 Recombinant Antibody (CBLG1-3209) (CBMAB-G5025-LY)

Datasheet

SDS

Target: GRK7

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-3209

Application*: WB

Mouse Anti-GRK7 Recombinant Antibody (4C4) (CBMAB-A3592-LY)

Datasheet

SDS

Target: GRK7

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 4C4

Application*: E, E

Rabbit Anti-GRK7 Recombinant Antibody (EG1448) (CBMAB-EN1729-LY)

Datasheet

SDS

Target: GRK7

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EG1448

Application*: WB: 1:500~1:1000 ELISA: 1:5000

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)