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Mouse Anti-GSS Recombinant Antibody (4B6) (CBMAB-G5332-LY)

This product is antibody recognizes GSS. The antibody 4B6 immunoassay techniques such as: ELISA, IHC-P, WB.
See all GSS antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4B6
Antibody Isotype
IgG1, κ
Application
ELISA, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glutathione synthetase
Introduction
Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008]
Entrez Gene ID
2937
UniProt ID
P48637
Alternative Names
Glutathione Synthetase; Glutathione Synthase; GSH Synthetase; EC 6.3.2.3; GSH-S; HEL-S-64p; HEL-S-88n; GSHS;
Function
Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7646467, PubMed:9215686).

Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes (PubMed:10369661).
Biological Process
Cellular amino acid metabolic process Source: ProtInc
Nervous system development Source: ProtInc
Response to cadmium ion Source: Ensembl
Response to oxidative stress Source: ProtInc
Cellular Location
Cytosol; Extracellular exosome
Involvement in disease
Glutathione synthetase deficiency (GSS deficiency):
Severe form characterized by an increased rate of hemolysis and defective function of the central nervous system.
Glutathione synthetase deficiency of erythrocytes (GLUSYNDE):
Mild form causing hemolytic anemia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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