GSS

Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq]
Full Name
glutathione synthetase
Function
Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7646467, PubMed:9215686).

Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes (PubMed:10369661).
Biological Process
Cellular amino acid metabolic process Source: ProtInc
Nervous system development Source: ProtInc
Response to cadmium ion Source: Ensembl
Response to oxidative stress Source: ProtInc
Cellular Location
Cytosol; Extracellular exosome
Involvement in disease
Glutathione synthetase deficiency (GSS deficiency):
Severe form characterized by an increased rate of hemolysis and defective function of the central nervous system.
Glutathione synthetase deficiency of erythrocytes (GLUSYNDE):
Mild form causing hemolytic anemia.
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Anti-GSS antibodies

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Mouse Anti-GSS Recombinant Antibody (CBLG1-1936) (CBMAB-G5344-LY)

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Target: GSS
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-1936
Application*: E, WB
Datasheet SDS

Mouse Anti-GSS Recombinant Antibody (CBLG1-1935) (CBMAB-G5343-LY)

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Target: GSS
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-1935
Application*: WB
Datasheet SDS

Mouse Anti-GSS Recombinant Antibody (CBLG1-1934) (CBMAB-G5342-LY)

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Target: GSS
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-1934
Application*: WB
Datasheet SDS

Mouse Anti-GSS Recombinant Antibody (CBLG1-3007) (CBMAB-G5341-LY)

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Target: GSS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat
Clone: CBLG1-3007
Application*: WB
Datasheet SDS

Mouse Anti-GSS Recombinant Antibody (CBLG1-3003) (CBMAB-G5337-LY)

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Target: GSS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-3003
Application*: WB
Datasheet SDS

Rabbit Anti-GSS Recombinant Antibody (CBLG1-3002) (CBMAB-G5336-LY)

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Target: GSS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLG1-3002
Application*: WB
Datasheet SDS

Mouse Anti-GSS Recombinant Antibody (9G363) (CBMAB-G5334-LY)

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Target: GSS
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 9G363
Application*: E, WB
Datasheet SDS

Mouse Anti-GSS Recombinant Antibody (5G4-2E9) (CBMAB-G5333-LY)

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Target: GSS
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5G4-2E9
Application*: E, WB
Datasheet SDS

Mouse Anti-GSS Recombinant Antibody (4B6) (CBMAB-G5332-LY)

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Target: GSS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4B6
Application*: E, P, WB
Datasheet SDS

Mouse Anti-GSS Recombinant Antibody (2F2) (CBMAB-G5330-LY)

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Target: GSS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat
Clone: 2F2
Application*: F
Datasheet SDS

Mouse Anti-GSS Recombinant Antibody (1B8) (CBMAB-G5328-LY)

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Target: GSS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B8
Application*: F
Datasheet SDS

Mouse Anti-GSS Recombinant Antibody (12F2) (CBMAB-G0873-LY)

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Target: GSS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 12F2
Application*: WB
Datasheet SDS

Mouse Anti-GSS Recombinant Antibody (CBFYH-0513) (CBMAB-H1386-FY)

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Target: GSS
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0513
Application*: E, WB
Datasheet SDS

Mouse Anti-GSS Recombinant Antibody (CBFYH-0512) (CBMAB-H1385-FY)

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Target: GSS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat
Clone: CBFYH-0512
Application*: WB, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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