GSS

Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq]

Full Name

glutathione synthetase

Function

Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7646467, PubMed:9215686).

Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes (PubMed:10369661).

Biological Process

Cellular amino acid metabolic process Source: ProtInc
Nervous system development Source: ProtInc
Response to cadmium ion Source: Ensembl
Response to oxidative stress Source: ProtInc

Cellular Location

Cytosol; Extracellular exosome

Involvement in disease

Glutathione synthetase deficiency (GSS deficiency):
Severe form characterized by an increased rate of hemolysis and defective function of the central nervous system.
Glutathione synthetase deficiency of erythrocytes (GLUSYNDE):
Mild form causing hemolytic anemia.

Anti-GSS antibodies

Mouse Anti-GSS Recombinant Antibody (4B6) (CBMAB-G5332-LY)

Datasheet

SDS

Target: GSS

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4B6

Application*: E, P, WB

Mouse Anti-GSS Recombinant Antibody (5G4-2E9) (CBMAB-G5333-LY)

Datasheet

SDS

Target: GSS

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 5G4-2E9

Application*: E, WB

Mouse Anti-GSS Recombinant Antibody (9G363) (CBMAB-G5334-LY)

Datasheet

SDS

Target: GSS

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 9G363

Application*: E, WB

Rabbit Anti-GSS Recombinant Antibody (CBLG1-3002) (CBMAB-G5336-LY)

Datasheet

SDS

Target: GSS

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBLG1-3002

Application*: WB

Mouse Anti-GSS Recombinant Antibody (CBLG1-3007) (CBMAB-G5341-LY)

Datasheet

SDS

Target: GSS

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Dog, Rat

Clone: CBLG1-3007

Application*: WB

Mouse Anti-GSS Recombinant Antibody (CBLG1-1934) (CBMAB-G5342-LY)

Datasheet

SDS

Target: GSS

Host: Mouse

Antibody Isotype: IgG

Specificity: Rat

Clone: CBLG1-1934

Application*: WB

Mouse Anti-GSS Recombinant Antibody (CBLG1-1935) (CBMAB-G5343-LY)

Datasheet

SDS

Target: GSS

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-1935

Application*: WB

Mouse Anti-GSS Recombinant Antibody (12F2) (CBMAB-G0873-LY)

Datasheet

SDS

Target: GSS

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 12F2

Application*: WB

Mouse Anti-GSS Recombinant Antibody (1B8) (CBMAB-G5328-LY)

Datasheet

SDS

Target: GSS

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1B8

Application*: F

Mouse Anti-GSS Recombinant Antibody (2F2) (CBMAB-G5330-LY)

Datasheet

SDS

Target: GSS

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Dog, Rat

Clone: 2F2

Application*: F

Mouse Anti-GSS Recombinant Antibody (CBLG1-3003) (CBMAB-G5337-LY)

Datasheet

SDS

Target: GSS

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-3003

Application*: WB

Mouse Anti-GSS Recombinant Antibody (CBLG1-1936) (CBMAB-G5344-LY)

Datasheet

SDS

Target: GSS

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-1936

Application*: E, WB

Mouse Anti-GSS Recombinant Antibody (CBFYH-0512) (CBMAB-H1385-FY)

Datasheet

SDS

Target: GSS

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Dog, Rat

Clone: CBFYH-0512

Application*: WB, F

Mouse Anti-GSS Recombinant Antibody (CBFYH-0513) (CBMAB-H1386-FY)

Datasheet

SDS

Target: GSS

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYH-0513

Application*: E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)